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Evaluation of central and peripheral neuropathy in patients with chronic obstructive pulmonary disease
BACKGROUND: The aim of the study was to investigate the frequency and characteristics of peripheral nervous system (PNS) and central nervous system (CNS) involvement in COPD. METHODS: The study included 41 COPD patients and 41 healthy volunteers. Electrophysiological studies were carried out: electr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995289/ https://www.ncbi.nlm.nih.gov/pubmed/29922052 http://dx.doi.org/10.2147/COPD.S159738 |
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author | Aras, Yeşim Güzey Aydemir, Yusuf Güngen, Belma Doğan Güngen, Adil Can |
author_facet | Aras, Yeşim Güzey Aydemir, Yusuf Güngen, Belma Doğan Güngen, Adil Can |
author_sort | Aras, Yeşim Güzey |
collection | PubMed |
description | BACKGROUND: The aim of the study was to investigate the frequency and characteristics of peripheral nervous system (PNS) and central nervous system (CNS) involvement in COPD. METHODS: The study included 41 COPD patients and 41 healthy volunteers. Electrophysiological studies were carried out: electromyography (EMG) and visual evoked potentials (VEPs). The median nerve, ulnar nerve, common peroneal nerve, and tibial nerve were evaluated for latency, amplitude, and conduction velocity. RESULTS: The mean age of patients with COPD was 61.8 years and disease duration 10.3 years. There was no difference between patient and control groups in terms of age, BMI, smoking status, or biochemical parameters. Upon VEP examination, latencies were significantly prolonged and amplitudes shortened in the patient group compared to the control group. In EMG measurements, conduction velocity and amplitudes in all nerves were low in the patient group. Similarly, latencies in all nerves were higher in patients with COPD. CONCLUSION: Central and peripheral nervous system involvement could develop in patients with moderate–severe COPD, and these patients should be monitored for neuropathic changes in combination with neurological examination. |
format | Online Article Text |
id | pubmed-5995289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59952892018-06-19 Evaluation of central and peripheral neuropathy in patients with chronic obstructive pulmonary disease Aras, Yeşim Güzey Aydemir, Yusuf Güngen, Belma Doğan Güngen, Adil Can Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND: The aim of the study was to investigate the frequency and characteristics of peripheral nervous system (PNS) and central nervous system (CNS) involvement in COPD. METHODS: The study included 41 COPD patients and 41 healthy volunteers. Electrophysiological studies were carried out: electromyography (EMG) and visual evoked potentials (VEPs). The median nerve, ulnar nerve, common peroneal nerve, and tibial nerve were evaluated for latency, amplitude, and conduction velocity. RESULTS: The mean age of patients with COPD was 61.8 years and disease duration 10.3 years. There was no difference between patient and control groups in terms of age, BMI, smoking status, or biochemical parameters. Upon VEP examination, latencies were significantly prolonged and amplitudes shortened in the patient group compared to the control group. In EMG measurements, conduction velocity and amplitudes in all nerves were low in the patient group. Similarly, latencies in all nerves were higher in patients with COPD. CONCLUSION: Central and peripheral nervous system involvement could develop in patients with moderate–severe COPD, and these patients should be monitored for neuropathic changes in combination with neurological examination. Dove Medical Press 2018-06-07 /pmc/articles/PMC5995289/ /pubmed/29922052 http://dx.doi.org/10.2147/COPD.S159738 Text en © 2018 Aras et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Aras, Yeşim Güzey Aydemir, Yusuf Güngen, Belma Doğan Güngen, Adil Can Evaluation of central and peripheral neuropathy in patients with chronic obstructive pulmonary disease |
title | Evaluation of central and peripheral neuropathy in patients with chronic obstructive pulmonary disease |
title_full | Evaluation of central and peripheral neuropathy in patients with chronic obstructive pulmonary disease |
title_fullStr | Evaluation of central and peripheral neuropathy in patients with chronic obstructive pulmonary disease |
title_full_unstemmed | Evaluation of central and peripheral neuropathy in patients with chronic obstructive pulmonary disease |
title_short | Evaluation of central and peripheral neuropathy in patients with chronic obstructive pulmonary disease |
title_sort | evaluation of central and peripheral neuropathy in patients with chronic obstructive pulmonary disease |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995289/ https://www.ncbi.nlm.nih.gov/pubmed/29922052 http://dx.doi.org/10.2147/COPD.S159738 |
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