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Sarcopenic obesity and cognitive performance
BACKGROUND: Sarcopenia and obesity both negatively impact health including cognitive function. Their coexistence, however, can pose an even higher threat likely surpassing their individual effects. We assessed the relationship of sarcopenic obesity with performance on global- and subdomain-specific...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995418/ https://www.ncbi.nlm.nih.gov/pubmed/29922049 http://dx.doi.org/10.2147/CIA.S164113 |
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author | Tolea, Magdalena I Chrisphonte, Stephanie Galvin, James E |
author_facet | Tolea, Magdalena I Chrisphonte, Stephanie Galvin, James E |
author_sort | Tolea, Magdalena I |
collection | PubMed |
description | BACKGROUND: Sarcopenia and obesity both negatively impact health including cognitive function. Their coexistence, however, can pose an even higher threat likely surpassing their individual effects. We assessed the relationship of sarcopenic obesity with performance on global- and subdomain-specific tests of cognition. PATIENTS AND METHODS: The study was a cross-sectional analysis of data from a series of community-based aging and memory studies. The sample consisted of a total of 353 participants with an average age of 69 years with a clinic visit and valid cognitive (eg, Montreal Cognitive Assessment, animal naming), functional (eg, grip strength, chair stands), and body composition (eg, muscle mass, body mass index, percent body fat) measurements. RESULTS: Sarcopenic obesity was associated with the lowest performance on global cognition (Est.(Definition1)=−2.85±1.38, p=0.039), followed by sarcopenia (Est.(Definition1)=−1.88±0.79, p=0.017) and obesity (Est.(Definition1)=−1.10±0.81, p=0.175) adjusted for sociodemographic factors. The latter, however, did not differ significantly from the comparison group consisting of older adults with neither sarcopenia nor obesity. Subdomain-specific analyses revealed executive function (Est.(Definition1)=−1.22±0.46 for sarcopenic obesity; Est.(Definition1)=−0.76±0.26 for sarcopenia; Est.(Definition1)=−0.52±0.27 for obesity all at p<0.05) and orientation (Est.(Definition1)=0.59±0.26 for sarcopenic obesity; Est.(Definition1)=−0.36±0.15 for sarcopenia; Est.(Definition1)=−0.29±0.15 all but obesity significant at p<0.05) as the individual cognitive skills likely to be impacted. Potential age-specific and depression effects are discussed. CONCLUSION: Sarcopenia alone and in combination with sarcopenic obesity can be used in clinical practice as indicators of probable cognitive impairment. At-risk older adults may benefit from programs addressing loss of cognitive function by maintaining/improving strength and preventing obesity. |
format | Online Article Text |
id | pubmed-5995418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59954182018-06-19 Sarcopenic obesity and cognitive performance Tolea, Magdalena I Chrisphonte, Stephanie Galvin, James E Clin Interv Aging Original Research BACKGROUND: Sarcopenia and obesity both negatively impact health including cognitive function. Their coexistence, however, can pose an even higher threat likely surpassing their individual effects. We assessed the relationship of sarcopenic obesity with performance on global- and subdomain-specific tests of cognition. PATIENTS AND METHODS: The study was a cross-sectional analysis of data from a series of community-based aging and memory studies. The sample consisted of a total of 353 participants with an average age of 69 years with a clinic visit and valid cognitive (eg, Montreal Cognitive Assessment, animal naming), functional (eg, grip strength, chair stands), and body composition (eg, muscle mass, body mass index, percent body fat) measurements. RESULTS: Sarcopenic obesity was associated with the lowest performance on global cognition (Est.(Definition1)=−2.85±1.38, p=0.039), followed by sarcopenia (Est.(Definition1)=−1.88±0.79, p=0.017) and obesity (Est.(Definition1)=−1.10±0.81, p=0.175) adjusted for sociodemographic factors. The latter, however, did not differ significantly from the comparison group consisting of older adults with neither sarcopenia nor obesity. Subdomain-specific analyses revealed executive function (Est.(Definition1)=−1.22±0.46 for sarcopenic obesity; Est.(Definition1)=−0.76±0.26 for sarcopenia; Est.(Definition1)=−0.52±0.27 for obesity all at p<0.05) and orientation (Est.(Definition1)=0.59±0.26 for sarcopenic obesity; Est.(Definition1)=−0.36±0.15 for sarcopenia; Est.(Definition1)=−0.29±0.15 all but obesity significant at p<0.05) as the individual cognitive skills likely to be impacted. Potential age-specific and depression effects are discussed. CONCLUSION: Sarcopenia alone and in combination with sarcopenic obesity can be used in clinical practice as indicators of probable cognitive impairment. At-risk older adults may benefit from programs addressing loss of cognitive function by maintaining/improving strength and preventing obesity. Dove Medical Press 2018-06-06 /pmc/articles/PMC5995418/ /pubmed/29922049 http://dx.doi.org/10.2147/CIA.S164113 Text en © 2018 Tolea et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Tolea, Magdalena I Chrisphonte, Stephanie Galvin, James E Sarcopenic obesity and cognitive performance |
title | Sarcopenic obesity and cognitive performance |
title_full | Sarcopenic obesity and cognitive performance |
title_fullStr | Sarcopenic obesity and cognitive performance |
title_full_unstemmed | Sarcopenic obesity and cognitive performance |
title_short | Sarcopenic obesity and cognitive performance |
title_sort | sarcopenic obesity and cognitive performance |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995418/ https://www.ncbi.nlm.nih.gov/pubmed/29922049 http://dx.doi.org/10.2147/CIA.S164113 |
work_keys_str_mv | AT toleamagdalenai sarcopenicobesityandcognitiveperformance AT chrisphontestephanie sarcopenicobesityandcognitiveperformance AT galvinjamese sarcopenicobesityandcognitiveperformance |