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Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1

Lyme disease is caused by spirochaetes of the Borrelia burgdorferi sensu lato genospecies. Complete genome assemblies are available for fewer than ten strains of Borrelia burgdorferi sensu stricto, the primary cause of Lyme disease in North America. MM1 is a sensu stricto strain originally isolated...

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Autores principales: Jabbari, Neda, Glusman, Gustavo, Joesch-Cohen, Lena M., Reddy, Panga Jaipal, Moritz, Robert L., Hood, Leroy, Lausted, Christopher G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995427/
https://www.ncbi.nlm.nih.gov/pubmed/29889842
http://dx.doi.org/10.1371/journal.pone.0198135
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author Jabbari, Neda
Glusman, Gustavo
Joesch-Cohen, Lena M.
Reddy, Panga Jaipal
Moritz, Robert L.
Hood, Leroy
Lausted, Christopher G.
author_facet Jabbari, Neda
Glusman, Gustavo
Joesch-Cohen, Lena M.
Reddy, Panga Jaipal
Moritz, Robert L.
Hood, Leroy
Lausted, Christopher G.
author_sort Jabbari, Neda
collection PubMed
description Lyme disease is caused by spirochaetes of the Borrelia burgdorferi sensu lato genospecies. Complete genome assemblies are available for fewer than ten strains of Borrelia burgdorferi sensu stricto, the primary cause of Lyme disease in North America. MM1 is a sensu stricto strain originally isolated in the midwestern United States. Aside from a small number of genes, the complete genome sequence of this strain has not been reported. Here we present the complete genome sequence of MM1 in relation to other sensu stricto strains and in terms of its Multi Locus Sequence Typing. Our results indicate that MM1 is a new sequence type which contains a conserved main chromosome and 15 plasmids. Our results include the first contiguous 28.5 kb assembly of lp28-8, a linear plasmid carrying the vls antigenic variation system, from a Borrelia burgdorferi sensu stricto strain.
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spelling pubmed-59954272018-06-21 Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1 Jabbari, Neda Glusman, Gustavo Joesch-Cohen, Lena M. Reddy, Panga Jaipal Moritz, Robert L. Hood, Leroy Lausted, Christopher G. PLoS One Research Article Lyme disease is caused by spirochaetes of the Borrelia burgdorferi sensu lato genospecies. Complete genome assemblies are available for fewer than ten strains of Borrelia burgdorferi sensu stricto, the primary cause of Lyme disease in North America. MM1 is a sensu stricto strain originally isolated in the midwestern United States. Aside from a small number of genes, the complete genome sequence of this strain has not been reported. Here we present the complete genome sequence of MM1 in relation to other sensu stricto strains and in terms of its Multi Locus Sequence Typing. Our results indicate that MM1 is a new sequence type which contains a conserved main chromosome and 15 plasmids. Our results include the first contiguous 28.5 kb assembly of lp28-8, a linear plasmid carrying the vls antigenic variation system, from a Borrelia burgdorferi sensu stricto strain. Public Library of Science 2018-06-11 /pmc/articles/PMC5995427/ /pubmed/29889842 http://dx.doi.org/10.1371/journal.pone.0198135 Text en © 2018 Jabbari et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Jabbari, Neda
Glusman, Gustavo
Joesch-Cohen, Lena M.
Reddy, Panga Jaipal
Moritz, Robert L.
Hood, Leroy
Lausted, Christopher G.
Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1
title Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1
title_full Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1
title_fullStr Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1
title_full_unstemmed Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1
title_short Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1
title_sort whole genome sequence and comparative analysis of borrelia burgdorferi mm1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995427/
https://www.ncbi.nlm.nih.gov/pubmed/29889842
http://dx.doi.org/10.1371/journal.pone.0198135
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