Cargando…

D-cis-Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo

PURPOSE: New perspectives are needed to understand decades of contradictory reports on the neuroprotective effects of the Cav1.2 L-type calcium channel blocker d-cis-diltiazem in retinitis pigmentosa (RP) models. Here, we address, in vivo, the following two knowledge gaps regarding d-cis-diltiazem&#...

Descripción completa

Detalles Bibliográficos
Autores principales:	Berkowitz, Bruce A., Podolsky, Robert H., Farrell, Benjamin, Lee, Hojun, Trepanier, Christopher, Berri, Ali M., Dernay, Kristin, Graffice, Emma, Shafie-Khorassani, Fatema, Kern, Timothy S., Roberts, Robin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2018
Materias:	Retinal Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995482/ https://www.ncbi.nlm.nih.gov/pubmed/30025125 http://dx.doi.org/10.1167/iovs.18-23829

Ejemplares similares

Dark Rearing Does Not Prevent Rod Oxidative Stress In Vivo in Pde6b(rd10) Mice
por: Berkowitz, Bruce A., et al.
Publicado: (2018)

Sodium Iodate Produces a Strain-Dependent Retinal Oxidative Stress Response Measured In Vivo Using QUEST MRI
por: Berkowitz, Bruce A., et al.
Publicado: (2017)

Rod Photoreceptor Neuroprotection in Dark-Reared Pde6brd10 Mice
por: Berkowitz, Bruce A., et al.
Publicado: (2020)

Mitochondrial Respiration in Outer Retina Contributes to Light-Evoked Increase in Hydration In Vivo
por: Berkowitz, Bruce A., et al.
Publicado: (2018)

Sema3A Reduces Sprouting of Adult Rod Photoreceptors In Vitro
por: Kung, Frank, et al.
Publicado: (2017)

MRI of Retinal Free Radical Production With Laminar Resolution In Vivo
por: Berkowitz, Bruce A., et al.
Publicado: (2016)

Potential of Small Molecule–Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa
por: Nakamura, Paul A., et al.
Publicado: (2016)

Abnormal Cone and Rod Photoreceptor Morphogenesis in gdf6a Mutant Zebrafish
por: Nadolski, Nathan J., et al.
Publicado: (2020)

Multiple Invagination Patterns and Synaptic Efficacy in Primate and Mouse Rod Synaptic Terminals
por: Tsukamoto, Yoshihiko, et al.
Publicado: (2022)

Phosphodiesterase Inhibitors Sildenafil and Vardenafil Reduce Zebrafish Rod Photoreceptor Outer Segment Shedding
por: Campbell, Leah J., et al.
Publicado: (2017)

Block of the cyclic GMP-gated channel of vertebrate rod and cone photoreceptors by l-cis-diltiazem
Publicado: (1992)

Critical Decrease in the Level of Axon Guidance Receptor ROBO1 in Rod Synaptic Terminals Is Followed by Axon Retraction
por: Appelbaum, Tatyana, et al.
Publicado: (2020)

Rescue of Rod Synapses by Induction of Ca(v) Alpha 1F in the Mature Ca(v)1.4 Knock-Out Mouse Retina
por: Laird, Joseph G., et al.
Publicado: (2019)

Correcting QUEST Magnetic Resonance Imaging–Sensitive Free Radical Production in the Outer Retina In Vivo Does Not Correct Reduced Visual Performance in 24-Month-Old C57BL/6J Mice
por: Berkowitz, Bruce A., et al.
Publicado: (2021)

Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy
por: Lessieur, Emma M., et al.
Publicado: (2021)

Melanopsin Phototransduction Contributes to Light-Evoked Choroidal Expansion and Rod L-Type Calcium Channel Function In Vivo
por: Berkowitz, Bruce A., et al.
Publicado: (2016)

Photoreceptor Degeneration Accompanies Vascular Changes in a Zebrafish Model of Diabetic Retinopathy
por: Ali, Zaheer, et al.
Publicado: (2020)

Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material
por: Zhang, Qitao, et al.
Publicado: (2019)

Multiple Bioenergy-Linked OCT Biomarkers Suggest Greater-Than-Normal Rod Mitochondria Activity Early in Experimental Alzheimer's Disease
por: Berkowitz, Bruce A., et al.
Publicado: (2023)

Role of RDS and Rhodopsin in Cngb1-Related Retinal Degeneration
por: Chakraborty, Dibyendu, et al.
Publicado: (2016)

Albumen Transport to Bruch's Membrane and RPE by Choriocapillaris Caveolae
por: Nakanishi, Masataka, et al.
Publicado: (2016)

Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Müller Glia–Derived Progenitors During Zebrafish Retinal Regeneration
por: Zhang, Shuqiang, et al.
Publicado: (2016)

Calpain-5 Expression in the Retina Localizes to Photoreceptor Synapses
por: Schaefer, Kellie A., et al.
Publicado: (2016)

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction
por: Sreekumar, Parameswaran G., et al.
Publicado: (2016)

PGC-1α Induces Human RPE Oxidative Metabolism and Antioxidant Capacity
por: Iacovelli, Jared, et al.
Publicado: (2016)

Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis
por: Arjunan, Pachiappan, et al.
Publicado: (2016)

Defective Angiogenesis and Intraretinal Bleeding in Mouse Models With Disrupted Inner Retinal Lamination
por: Simmons, Aaron B., et al.
Publicado: (2016)

A Targeted Inhibitor of the Alternative Complement Pathway Accelerates Recovery From Smoke-Induced Ocular Injury
por: Woodell, Alex, et al.
Publicado: (2016)

N-Acetylcysteine Amide Protects Against Oxidative Stress–Induced Microparticle Release From Human Retinal Pigment Epithelial Cells
por: Carver, Kyle A., et al.
Publicado: (2016)

Mutation of wrb, a Component of the Guided Entry of Tail-Anchored Protein Pathway, Disrupts Photoreceptor Synapse Structure and Function
por: Daniele, Lauren L., et al.
Publicado: (2016)

Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages
por: Collery, Ross F., et al.
Publicado: (2016)

Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model
por: Pilgrim, Matthew G., et al.
Publicado: (2017)

The Ciliopathy Gene ahi1 Is Required for Zebrafish Cone Photoreceptor Outer Segment Morphogenesis and Survival
por: Lessieur, Emma M., et al.
Publicado: (2017)

Crx(Rdy) Cat: A Large Animal Model for CRX-Associated Leber Congenital Amaurosis
por: Occelli, Laurence M., et al.
Publicado: (2016)

Beneficial Effects of Berberine on Oxidized LDL-Induced Cytotoxicity to Human Retinal Müller Cells
por: Fu, Dongxu, et al.
Publicado: (2016)

Peripheral Blood Mitochondrial DNA Damage as a Potential Noninvasive Biomarker of Diabetic Retinopathy
por: Mishra, Manish, et al.
Publicado: (2016)

Acute Stress Responses Are Early Molecular Events of Retinal Degeneration in Abca4(−/−)Rdh8(−/−) Mice After Light Exposure
por: Parmar, Tanu, et al.
Publicado: (2016)

RhoA Signaling and Synaptic Damage Occur Within Hours in a Live Pig Model of CNS Injury, Retinal Detachment
por: Wang, Jianfeng, et al.
Publicado: (2016)

Rapid, Dynamic Activation of Müller Glial Stem Cell Responses in Zebrafish
por: Sifuentes, Christopher J., et al.
Publicado: (2016)

The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions
por: Ma, Jacey H., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_192sl4ca9rtrhbnmlshks9icbi