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The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins
The endoplasmic reticulum (ER) supports biosynthesis of proteins with diverse transmembrane domain (TMD) lengths and hydrophobicity. Features in transmembrane domains such as charged residues in ion channels are often functionally important, but could pose a challenge during cotranslational membrane...
Autores principales: | Shurtleff, Matthew J, Itzhak, Daniel N, Hussmann, Jeffrey A, Schirle Oakdale, Nicole T, Costa, Elizabeth A, Jonikas, Martin, Weibezahn, Jimena, Popova, Katerina D, Jan, Calvin H, Sinitcyn, Pavel, Vembar, Shruthi S, Hernandez, Hilda, Cox, Jürgen, Burlingame, Alma L, Brodsky, Jeffrey L, Frost, Adam, Borner, Georg HH, Weissman, Jonathan S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995541/ https://www.ncbi.nlm.nih.gov/pubmed/29809151 http://dx.doi.org/10.7554/eLife.37018 |
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