Cargando…
Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish
The differentiation of the lateral plate mesoderm cells into heart field cells constitutes a critical step in the development of cardiac tissue and the genesis of functional cardiomyocytes. Hippo signaling controls cardiomyocyte proliferation, but the role of Hippo signaling during early cardiogenes...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995544/ https://www.ncbi.nlm.nih.gov/pubmed/29809141 http://dx.doi.org/10.7554/eLife.29106 |
_version_ | 1783330639249932288 |
---|---|
author | Fukui, Hajime Miyazaki, Takahiro Chow, Renee Wei-Yan Ishikawa, Hiroyuki Nakajima, Hiroyuki Vermot, Julien Mochizuki, Naoki |
author_facet | Fukui, Hajime Miyazaki, Takahiro Chow, Renee Wei-Yan Ishikawa, Hiroyuki Nakajima, Hiroyuki Vermot, Julien Mochizuki, Naoki |
author_sort | Fukui, Hajime |
collection | PubMed |
description | The differentiation of the lateral plate mesoderm cells into heart field cells constitutes a critical step in the development of cardiac tissue and the genesis of functional cardiomyocytes. Hippo signaling controls cardiomyocyte proliferation, but the role of Hippo signaling during early cardiogenesis remains unclear. Here, we show that Hippo signaling regulates atrial cell number by specifying the developmental potential of cells within the anterior lateral plate mesoderm (ALPM), which are incorporated into the venous pole of the heart tube and ultimately into the atrium of the heart. We demonstrate that Hippo signaling acts through large tumor suppressor kinase 1/2 to modulate BMP signaling and the expression of hand2, a key transcription factor that is involved in the differentiation of atrial cardiomyocytes. Collectively, these results demonstrate that Hippo signaling defines venous pole cardiomyocyte number by modulating both the number and the identity of the ALPM cells that will populate the atrium of the heart. |
format | Online Article Text |
id | pubmed-5995544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59955442018-06-13 Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish Fukui, Hajime Miyazaki, Takahiro Chow, Renee Wei-Yan Ishikawa, Hiroyuki Nakajima, Hiroyuki Vermot, Julien Mochizuki, Naoki eLife Developmental Biology The differentiation of the lateral plate mesoderm cells into heart field cells constitutes a critical step in the development of cardiac tissue and the genesis of functional cardiomyocytes. Hippo signaling controls cardiomyocyte proliferation, but the role of Hippo signaling during early cardiogenesis remains unclear. Here, we show that Hippo signaling regulates atrial cell number by specifying the developmental potential of cells within the anterior lateral plate mesoderm (ALPM), which are incorporated into the venous pole of the heart tube and ultimately into the atrium of the heart. We demonstrate that Hippo signaling acts through large tumor suppressor kinase 1/2 to modulate BMP signaling and the expression of hand2, a key transcription factor that is involved in the differentiation of atrial cardiomyocytes. Collectively, these results demonstrate that Hippo signaling defines venous pole cardiomyocyte number by modulating both the number and the identity of the ALPM cells that will populate the atrium of the heart. eLife Sciences Publications, Ltd 2018-05-29 /pmc/articles/PMC5995544/ /pubmed/29809141 http://dx.doi.org/10.7554/eLife.29106 Text en © 2018, Fukui et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology Fukui, Hajime Miyazaki, Takahiro Chow, Renee Wei-Yan Ishikawa, Hiroyuki Nakajima, Hiroyuki Vermot, Julien Mochizuki, Naoki Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish |
title | Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish |
title_full | Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish |
title_fullStr | Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish |
title_full_unstemmed | Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish |
title_short | Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish |
title_sort | hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish |
topic | Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995544/ https://www.ncbi.nlm.nih.gov/pubmed/29809141 http://dx.doi.org/10.7554/eLife.29106 |
work_keys_str_mv | AT fukuihajime hipposignalingdeterminesthenumberofvenouspolecellsthatoriginatefromtheanteriorlateralplatemesoderminzebrafish AT miyazakitakahiro hipposignalingdeterminesthenumberofvenouspolecellsthatoriginatefromtheanteriorlateralplatemesoderminzebrafish AT chowreneeweiyan hipposignalingdeterminesthenumberofvenouspolecellsthatoriginatefromtheanteriorlateralplatemesoderminzebrafish AT ishikawahiroyuki hipposignalingdeterminesthenumberofvenouspolecellsthatoriginatefromtheanteriorlateralplatemesoderminzebrafish AT nakajimahiroyuki hipposignalingdeterminesthenumberofvenouspolecellsthatoriginatefromtheanteriorlateralplatemesoderminzebrafish AT vermotjulien hipposignalingdeterminesthenumberofvenouspolecellsthatoriginatefromtheanteriorlateralplatemesoderminzebrafish AT mochizukinaoki hipposignalingdeterminesthenumberofvenouspolecellsthatoriginatefromtheanteriorlateralplatemesoderminzebrafish |