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Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish

The differentiation of the lateral plate mesoderm cells into heart field cells constitutes a critical step in the development of cardiac tissue and the genesis of functional cardiomyocytes. Hippo signaling controls cardiomyocyte proliferation, but the role of Hippo signaling during early cardiogenes...

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Autores principales: Fukui, Hajime, Miyazaki, Takahiro, Chow, Renee Wei-Yan, Ishikawa, Hiroyuki, Nakajima, Hiroyuki, Vermot, Julien, Mochizuki, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995544/
https://www.ncbi.nlm.nih.gov/pubmed/29809141
http://dx.doi.org/10.7554/eLife.29106
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author Fukui, Hajime
Miyazaki, Takahiro
Chow, Renee Wei-Yan
Ishikawa, Hiroyuki
Nakajima, Hiroyuki
Vermot, Julien
Mochizuki, Naoki
author_facet Fukui, Hajime
Miyazaki, Takahiro
Chow, Renee Wei-Yan
Ishikawa, Hiroyuki
Nakajima, Hiroyuki
Vermot, Julien
Mochizuki, Naoki
author_sort Fukui, Hajime
collection PubMed
description The differentiation of the lateral plate mesoderm cells into heart field cells constitutes a critical step in the development of cardiac tissue and the genesis of functional cardiomyocytes. Hippo signaling controls cardiomyocyte proliferation, but the role of Hippo signaling during early cardiogenesis remains unclear. Here, we show that Hippo signaling regulates atrial cell number by specifying the developmental potential of cells within the anterior lateral plate mesoderm (ALPM), which are incorporated into the venous pole of the heart tube and ultimately into the atrium of the heart. We demonstrate that Hippo signaling acts through large tumor suppressor kinase 1/2 to modulate BMP signaling and the expression of hand2, a key transcription factor that is involved in the differentiation of atrial cardiomyocytes. Collectively, these results demonstrate that Hippo signaling defines venous pole cardiomyocyte number by modulating both the number and the identity of the ALPM cells that will populate the atrium of the heart.
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spelling pubmed-59955442018-06-13 Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish Fukui, Hajime Miyazaki, Takahiro Chow, Renee Wei-Yan Ishikawa, Hiroyuki Nakajima, Hiroyuki Vermot, Julien Mochizuki, Naoki eLife Developmental Biology The differentiation of the lateral plate mesoderm cells into heart field cells constitutes a critical step in the development of cardiac tissue and the genesis of functional cardiomyocytes. Hippo signaling controls cardiomyocyte proliferation, but the role of Hippo signaling during early cardiogenesis remains unclear. Here, we show that Hippo signaling regulates atrial cell number by specifying the developmental potential of cells within the anterior lateral plate mesoderm (ALPM), which are incorporated into the venous pole of the heart tube and ultimately into the atrium of the heart. We demonstrate that Hippo signaling acts through large tumor suppressor kinase 1/2 to modulate BMP signaling and the expression of hand2, a key transcription factor that is involved in the differentiation of atrial cardiomyocytes. Collectively, these results demonstrate that Hippo signaling defines venous pole cardiomyocyte number by modulating both the number and the identity of the ALPM cells that will populate the atrium of the heart. eLife Sciences Publications, Ltd 2018-05-29 /pmc/articles/PMC5995544/ /pubmed/29809141 http://dx.doi.org/10.7554/eLife.29106 Text en © 2018, Fukui et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Developmental Biology
Fukui, Hajime
Miyazaki, Takahiro
Chow, Renee Wei-Yan
Ishikawa, Hiroyuki
Nakajima, Hiroyuki
Vermot, Julien
Mochizuki, Naoki
Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish
title Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish
title_full Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish
title_fullStr Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish
title_full_unstemmed Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish
title_short Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish
title_sort hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish
topic Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995544/
https://www.ncbi.nlm.nih.gov/pubmed/29809141
http://dx.doi.org/10.7554/eLife.29106
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