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Decorrelation Signal of Diabetic Hyperreflective Foci on Optical Coherence Tomography Angiography

Diabetic hyperreflective foci in the outer retinal layers are a clinically relevant finding on optical coherence tomography (OCT) images, although their characteristics remain to be elucidated. Here we investigated the decorrelation signal around hyperreflective foci on OCT angiography (OCTA) images...

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Autores principales: Murakami, Tomoaki, Suzuma, Kiyoshi, Dodo, Yoko, Yoshitake, Tatsuya, Yasukura, Shota, Nakanishi, Hideo, Fujimoto, Masahiro, Oishi, Maho, Tsujikawa, Akitaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995832/
https://www.ncbi.nlm.nih.gov/pubmed/29892079
http://dx.doi.org/10.1038/s41598-018-27192-9
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author Murakami, Tomoaki
Suzuma, Kiyoshi
Dodo, Yoko
Yoshitake, Tatsuya
Yasukura, Shota
Nakanishi, Hideo
Fujimoto, Masahiro
Oishi, Maho
Tsujikawa, Akitaka
author_facet Murakami, Tomoaki
Suzuma, Kiyoshi
Dodo, Yoko
Yoshitake, Tatsuya
Yasukura, Shota
Nakanishi, Hideo
Fujimoto, Masahiro
Oishi, Maho
Tsujikawa, Akitaka
author_sort Murakami, Tomoaki
collection PubMed
description Diabetic hyperreflective foci in the outer retinal layers are a clinically relevant finding on optical coherence tomography (OCT) images, although their characteristics remain to be elucidated. Here we investigated the decorrelation signal around hyperreflective foci on OCT angiography (OCTA) images in diabetic retinopathy (DR). We retrospectively reviewed sufficient quality OCTA images from 102 eyes of 66 patients that were obtained using split-spectrum amplitude-decorrelation angiography algorithm. Most confluent hyperreflective foci were randomly deposited or appeared in a radiating array on the en-face structural OCT images in the inner nuclear layer (INL) or Henle’s fiber layer (HFL), respectively. Within the INL, hyperreflective foci were not accompanied by decorrelation signals and attached to capillaries on OCTA images. Decorrelation signals were sometimes delineated in hyperreflective foci in the HFL and other times appeared to be pseudopod-like or wrapping around hyperreflective foci, referred to as reflectance-decorrelated foci. The decorrelation signal intensity of hyperreflective foci in the HFL was associated with logMAR VA (R = 0.553, P < 0.001) and central subfield thickness (R = 0.408, P < 0.001) but not with DR severity. These data suggest that reflectance-decorrelated foci on OCTA images are clinically relevant as well as shed lights on the properties in diabetic hyperreflective foci.
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spelling pubmed-59958322018-06-21 Decorrelation Signal of Diabetic Hyperreflective Foci on Optical Coherence Tomography Angiography Murakami, Tomoaki Suzuma, Kiyoshi Dodo, Yoko Yoshitake, Tatsuya Yasukura, Shota Nakanishi, Hideo Fujimoto, Masahiro Oishi, Maho Tsujikawa, Akitaka Sci Rep Article Diabetic hyperreflective foci in the outer retinal layers are a clinically relevant finding on optical coherence tomography (OCT) images, although their characteristics remain to be elucidated. Here we investigated the decorrelation signal around hyperreflective foci on OCT angiography (OCTA) images in diabetic retinopathy (DR). We retrospectively reviewed sufficient quality OCTA images from 102 eyes of 66 patients that were obtained using split-spectrum amplitude-decorrelation angiography algorithm. Most confluent hyperreflective foci were randomly deposited or appeared in a radiating array on the en-face structural OCT images in the inner nuclear layer (INL) or Henle’s fiber layer (HFL), respectively. Within the INL, hyperreflective foci were not accompanied by decorrelation signals and attached to capillaries on OCTA images. Decorrelation signals were sometimes delineated in hyperreflective foci in the HFL and other times appeared to be pseudopod-like or wrapping around hyperreflective foci, referred to as reflectance-decorrelated foci. The decorrelation signal intensity of hyperreflective foci in the HFL was associated with logMAR VA (R = 0.553, P < 0.001) and central subfield thickness (R = 0.408, P < 0.001) but not with DR severity. These data suggest that reflectance-decorrelated foci on OCTA images are clinically relevant as well as shed lights on the properties in diabetic hyperreflective foci. Nature Publishing Group UK 2018-06-11 /pmc/articles/PMC5995832/ /pubmed/29892079 http://dx.doi.org/10.1038/s41598-018-27192-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Murakami, Tomoaki
Suzuma, Kiyoshi
Dodo, Yoko
Yoshitake, Tatsuya
Yasukura, Shota
Nakanishi, Hideo
Fujimoto, Masahiro
Oishi, Maho
Tsujikawa, Akitaka
Decorrelation Signal of Diabetic Hyperreflective Foci on Optical Coherence Tomography Angiography
title Decorrelation Signal of Diabetic Hyperreflective Foci on Optical Coherence Tomography Angiography
title_full Decorrelation Signal of Diabetic Hyperreflective Foci on Optical Coherence Tomography Angiography
title_fullStr Decorrelation Signal of Diabetic Hyperreflective Foci on Optical Coherence Tomography Angiography
title_full_unstemmed Decorrelation Signal of Diabetic Hyperreflective Foci on Optical Coherence Tomography Angiography
title_short Decorrelation Signal of Diabetic Hyperreflective Foci on Optical Coherence Tomography Angiography
title_sort decorrelation signal of diabetic hyperreflective foci on optical coherence tomography angiography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995832/
https://www.ncbi.nlm.nih.gov/pubmed/29892079
http://dx.doi.org/10.1038/s41598-018-27192-9
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