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Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995836/ https://www.ncbi.nlm.nih.gov/pubmed/29892050 http://dx.doi.org/10.1038/s41467-018-04109-8 |
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author | Dadaev, Tokhir Saunders, Edward J. Newcombe, Paul J. Anokian, Ezequiel Leongamornlert, Daniel A. Brook, Mark N. Cieza-Borrella, Clara Mijuskovic, Martina Wakerell, Sarah Olama, Ali Amin Al Schumacher, Fredrick R. Berndt, Sonja I. Benlloch, Sara Ahmed, Mahbubl Goh, Chee Sheng, Xin Zhang, Zhuo Muir, Kenneth Govindasami, Koveela Lophatananon, Artitaya Stevens, Victoria L. Gapstur, Susan M. Carter, Brian D. Tangen, Catherine M. Goodman, Phyllis Thompson, Ian M. Batra, Jyotsna Chambers, Suzanne Moya, Leire Clements, Judith Horvath, Lisa Tilley, Wayne Risbridger, Gail Gronberg, Henrik Aly, Markus Nordström, Tobias Pharoah, Paul Pashayan, Nora Schleutker, Johanna Tammela, Teuvo L. J. Sipeky, Csilla Auvinen, Anssi Albanes, Demetrius Weinstein, Stephanie Wolk, Alicja Hakansson, Niclas West, Catharine Dunning, Alison M. Burnet, Neil Mucci, Lorelei Giovannucci, Edward Andriole, Gerald Cussenot, Olivier Cancel-Tassin, Géraldine Koutros, Stella Freeman, Laura E. Beane Sorensen, Karina Dalsgaard Orntoft, Torben Falck Borre, Michael Maehle, Lovise Grindedal, Eli Marie Neal, David E. Donovan, Jenny L. Hamdy, Freddie C. Martin, Richard M. Travis, Ruth C. Key, Tim J. Hamilton, Robert J. Fleshner, Neil E. Finelli, Antonio Ingles, Sue Ann Stern, Mariana C. Rosenstein, Barry Kerns, Sarah Ostrer, Harry Lu, Yong-Jie Zhang, Hong-Wei Feng, Ninghan Mao, Xueying Guo, Xin Wang, Guomin Sun, Zan Giles, Graham G. Southey, Melissa C. MacInnis, Robert J. FitzGerald, Liesel M. Kibel, Adam S. Drake, Bettina F. Vega, Ana Gómez-Caamaño, Antonio Fachal, Laura Szulkin, Robert Eklund, Martin Kogevinas, Manolis Llorca, Javier Castaño-Vinyals, Gemma Penney, Kathryn L. Stampfer, Meir Park, Jong Y. Sellers, Thomas A. Lin, Hui-Yi Stanford, Janet L. Cybulski, Cezary Wokolorczyk, Dominika Lubinski, Jan Ostrander, Elaine A. Geybels, Milan S. Nordestgaard, Børge G. Nielsen, Sune F. Weisher, Maren Bisbjerg, Rasmus Røder, Martin Andreas Iversen, Peter Brenner, Hermann Cuk, Katarina Holleczek, Bernd Maier, Christiane Luedeke, Manuel Schnoeller, Thomas Kim, Jeri Logothetis, Christopher J. John, Esther M. Teixeira, Manuel R. Paulo, Paula Cardoso, Marta Neuhausen, Susan L. Steele, Linda Ding, Yuan Chun De Ruyck, Kim De Meerleer, Gert Ost, Piet Razack, Azad Lim, Jasmine Teo, Soo-Hwang Lin, Daniel W. Newcomb, Lisa F. Lessel, Davor Gamulin, Marija Kulis, Tomislav Kaneva, Radka Usmani, Nawaid Slavov, Chavdar Mitev, Vanio Parliament, Matthew Singhal, Sandeep Claessens, Frank Joniau, Steven Van den Broeck, Thomas Larkin, Samantha Townsend, Paul A. Aukim-Hastie, Claire Gago-Dominguez, Manuela Castelao, Jose Esteban Martinez, Maria Elena Roobol, Monique J. Jenster, Guido van Schaik, Ron H. N. Menegaux, Florence Truong, Thérèse Koudou, Yves Akoli Xu, Jianfeng Khaw, Kay-Tee Cannon-Albright, Lisa Pandha, Hardev Michael, Agnieszka Kierzek, Andrzej Thibodeau, Stephen N. McDonnell, Shannon K. Schaid, Daniel J. Lindstrom, Sara Turman, Constance Ma, Jing Hunter, David J. Riboli, Elio Siddiq, Afshan Canzian, Federico Kolonel, Laurence N. Le Marchand, Loic Hoover, Robert N. Machiela, Mitchell J. Kraft, Peter Freedman, Matthew Wiklund, Fredrik Chanock, Stephen Henderson, Brian E. Easton, Douglas F. Haiman, Christopher A. Eeles, Rosalind A. Conti, David V. Kote-Jarai, Zsofia |
author_facet | Dadaev, Tokhir Saunders, Edward J. Newcombe, Paul J. Anokian, Ezequiel Leongamornlert, Daniel A. Brook, Mark N. Cieza-Borrella, Clara Mijuskovic, Martina Wakerell, Sarah Olama, Ali Amin Al Schumacher, Fredrick R. Berndt, Sonja I. Benlloch, Sara Ahmed, Mahbubl Goh, Chee Sheng, Xin Zhang, Zhuo Muir, Kenneth Govindasami, Koveela Lophatananon, Artitaya Stevens, Victoria L. Gapstur, Susan M. Carter, Brian D. Tangen, Catherine M. Goodman, Phyllis Thompson, Ian M. Batra, Jyotsna Chambers, Suzanne Moya, Leire Clements, Judith Horvath, Lisa Tilley, Wayne Risbridger, Gail Gronberg, Henrik Aly, Markus Nordström, Tobias Pharoah, Paul Pashayan, Nora Schleutker, Johanna Tammela, Teuvo L. J. Sipeky, Csilla Auvinen, Anssi Albanes, Demetrius Weinstein, Stephanie Wolk, Alicja Hakansson, Niclas West, Catharine Dunning, Alison M. Burnet, Neil Mucci, Lorelei Giovannucci, Edward Andriole, Gerald Cussenot, Olivier Cancel-Tassin, Géraldine Koutros, Stella Freeman, Laura E. Beane Sorensen, Karina Dalsgaard Orntoft, Torben Falck Borre, Michael Maehle, Lovise Grindedal, Eli Marie Neal, David E. Donovan, Jenny L. Hamdy, Freddie C. Martin, Richard M. Travis, Ruth C. Key, Tim J. Hamilton, Robert J. Fleshner, Neil E. Finelli, Antonio Ingles, Sue Ann Stern, Mariana C. Rosenstein, Barry Kerns, Sarah Ostrer, Harry Lu, Yong-Jie Zhang, Hong-Wei Feng, Ninghan Mao, Xueying Guo, Xin Wang, Guomin Sun, Zan Giles, Graham G. Southey, Melissa C. MacInnis, Robert J. FitzGerald, Liesel M. Kibel, Adam S. Drake, Bettina F. Vega, Ana Gómez-Caamaño, Antonio Fachal, Laura Szulkin, Robert Eklund, Martin Kogevinas, Manolis Llorca, Javier Castaño-Vinyals, Gemma Penney, Kathryn L. Stampfer, Meir Park, Jong Y. Sellers, Thomas A. Lin, Hui-Yi Stanford, Janet L. Cybulski, Cezary Wokolorczyk, Dominika Lubinski, Jan Ostrander, Elaine A. Geybels, Milan S. Nordestgaard, Børge G. Nielsen, Sune F. Weisher, Maren Bisbjerg, Rasmus Røder, Martin Andreas Iversen, Peter Brenner, Hermann Cuk, Katarina Holleczek, Bernd Maier, Christiane Luedeke, Manuel Schnoeller, Thomas Kim, Jeri Logothetis, Christopher J. John, Esther M. Teixeira, Manuel R. Paulo, Paula Cardoso, Marta Neuhausen, Susan L. Steele, Linda Ding, Yuan Chun De Ruyck, Kim De Meerleer, Gert Ost, Piet Razack, Azad Lim, Jasmine Teo, Soo-Hwang Lin, Daniel W. Newcomb, Lisa F. Lessel, Davor Gamulin, Marija Kulis, Tomislav Kaneva, Radka Usmani, Nawaid Slavov, Chavdar Mitev, Vanio Parliament, Matthew Singhal, Sandeep Claessens, Frank Joniau, Steven Van den Broeck, Thomas Larkin, Samantha Townsend, Paul A. Aukim-Hastie, Claire Gago-Dominguez, Manuela Castelao, Jose Esteban Martinez, Maria Elena Roobol, Monique J. Jenster, Guido van Schaik, Ron H. N. Menegaux, Florence Truong, Thérèse Koudou, Yves Akoli Xu, Jianfeng Khaw, Kay-Tee Cannon-Albright, Lisa Pandha, Hardev Michael, Agnieszka Kierzek, Andrzej Thibodeau, Stephen N. McDonnell, Shannon K. Schaid, Daniel J. Lindstrom, Sara Turman, Constance Ma, Jing Hunter, David J. Riboli, Elio Siddiq, Afshan Canzian, Federico Kolonel, Laurence N. Le Marchand, Loic Hoover, Robert N. Machiela, Mitchell J. Kraft, Peter Freedman, Matthew Wiklund, Fredrik Chanock, Stephen Henderson, Brian E. Easton, Douglas F. Haiman, Christopher A. Eeles, Rosalind A. Conti, David V. Kote-Jarai, Zsofia |
author_sort | Dadaev, Tokhir |
collection | PubMed |
description | Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. |
format | Online Article Text |
id | pubmed-5995836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59958362018-06-13 Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants Dadaev, Tokhir Saunders, Edward J. Newcombe, Paul J. Anokian, Ezequiel Leongamornlert, Daniel A. Brook, Mark N. Cieza-Borrella, Clara Mijuskovic, Martina Wakerell, Sarah Olama, Ali Amin Al Schumacher, Fredrick R. Berndt, Sonja I. Benlloch, Sara Ahmed, Mahbubl Goh, Chee Sheng, Xin Zhang, Zhuo Muir, Kenneth Govindasami, Koveela Lophatananon, Artitaya Stevens, Victoria L. Gapstur, Susan M. Carter, Brian D. Tangen, Catherine M. Goodman, Phyllis Thompson, Ian M. Batra, Jyotsna Chambers, Suzanne Moya, Leire Clements, Judith Horvath, Lisa Tilley, Wayne Risbridger, Gail Gronberg, Henrik Aly, Markus Nordström, Tobias Pharoah, Paul Pashayan, Nora Schleutker, Johanna Tammela, Teuvo L. J. Sipeky, Csilla Auvinen, Anssi Albanes, Demetrius Weinstein, Stephanie Wolk, Alicja Hakansson, Niclas West, Catharine Dunning, Alison M. Burnet, Neil Mucci, Lorelei Giovannucci, Edward Andriole, Gerald Cussenot, Olivier Cancel-Tassin, Géraldine Koutros, Stella Freeman, Laura E. Beane Sorensen, Karina Dalsgaard Orntoft, Torben Falck Borre, Michael Maehle, Lovise Grindedal, Eli Marie Neal, David E. Donovan, Jenny L. Hamdy, Freddie C. Martin, Richard M. Travis, Ruth C. Key, Tim J. Hamilton, Robert J. Fleshner, Neil E. Finelli, Antonio Ingles, Sue Ann Stern, Mariana C. Rosenstein, Barry Kerns, Sarah Ostrer, Harry Lu, Yong-Jie Zhang, Hong-Wei Feng, Ninghan Mao, Xueying Guo, Xin Wang, Guomin Sun, Zan Giles, Graham G. Southey, Melissa C. MacInnis, Robert J. FitzGerald, Liesel M. Kibel, Adam S. Drake, Bettina F. Vega, Ana Gómez-Caamaño, Antonio Fachal, Laura Szulkin, Robert Eklund, Martin Kogevinas, Manolis Llorca, Javier Castaño-Vinyals, Gemma Penney, Kathryn L. Stampfer, Meir Park, Jong Y. Sellers, Thomas A. Lin, Hui-Yi Stanford, Janet L. Cybulski, Cezary Wokolorczyk, Dominika Lubinski, Jan Ostrander, Elaine A. Geybels, Milan S. Nordestgaard, Børge G. Nielsen, Sune F. Weisher, Maren Bisbjerg, Rasmus Røder, Martin Andreas Iversen, Peter Brenner, Hermann Cuk, Katarina Holleczek, Bernd Maier, Christiane Luedeke, Manuel Schnoeller, Thomas Kim, Jeri Logothetis, Christopher J. John, Esther M. Teixeira, Manuel R. Paulo, Paula Cardoso, Marta Neuhausen, Susan L. Steele, Linda Ding, Yuan Chun De Ruyck, Kim De Meerleer, Gert Ost, Piet Razack, Azad Lim, Jasmine Teo, Soo-Hwang Lin, Daniel W. Newcomb, Lisa F. Lessel, Davor Gamulin, Marija Kulis, Tomislav Kaneva, Radka Usmani, Nawaid Slavov, Chavdar Mitev, Vanio Parliament, Matthew Singhal, Sandeep Claessens, Frank Joniau, Steven Van den Broeck, Thomas Larkin, Samantha Townsend, Paul A. Aukim-Hastie, Claire Gago-Dominguez, Manuela Castelao, Jose Esteban Martinez, Maria Elena Roobol, Monique J. Jenster, Guido van Schaik, Ron H. N. Menegaux, Florence Truong, Thérèse Koudou, Yves Akoli Xu, Jianfeng Khaw, Kay-Tee Cannon-Albright, Lisa Pandha, Hardev Michael, Agnieszka Kierzek, Andrzej Thibodeau, Stephen N. McDonnell, Shannon K. Schaid, Daniel J. Lindstrom, Sara Turman, Constance Ma, Jing Hunter, David J. Riboli, Elio Siddiq, Afshan Canzian, Federico Kolonel, Laurence N. Le Marchand, Loic Hoover, Robert N. Machiela, Mitchell J. Kraft, Peter Freedman, Matthew Wiklund, Fredrik Chanock, Stephen Henderson, Brian E. Easton, Douglas F. Haiman, Christopher A. Eeles, Rosalind A. Conti, David V. Kote-Jarai, Zsofia Nat Commun Article Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. Nature Publishing Group UK 2018-06-11 /pmc/articles/PMC5995836/ /pubmed/29892050 http://dx.doi.org/10.1038/s41467-018-04109-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Dadaev, Tokhir Saunders, Edward J. Newcombe, Paul J. Anokian, Ezequiel Leongamornlert, Daniel A. Brook, Mark N. Cieza-Borrella, Clara Mijuskovic, Martina Wakerell, Sarah Olama, Ali Amin Al Schumacher, Fredrick R. Berndt, Sonja I. Benlloch, Sara Ahmed, Mahbubl Goh, Chee Sheng, Xin Zhang, Zhuo Muir, Kenneth Govindasami, Koveela Lophatananon, Artitaya Stevens, Victoria L. Gapstur, Susan M. Carter, Brian D. Tangen, Catherine M. Goodman, Phyllis Thompson, Ian M. Batra, Jyotsna Chambers, Suzanne Moya, Leire Clements, Judith Horvath, Lisa Tilley, Wayne Risbridger, Gail Gronberg, Henrik Aly, Markus Nordström, Tobias Pharoah, Paul Pashayan, Nora Schleutker, Johanna Tammela, Teuvo L. J. Sipeky, Csilla Auvinen, Anssi Albanes, Demetrius Weinstein, Stephanie Wolk, Alicja Hakansson, Niclas West, Catharine Dunning, Alison M. Burnet, Neil Mucci, Lorelei Giovannucci, Edward Andriole, Gerald Cussenot, Olivier Cancel-Tassin, Géraldine Koutros, Stella Freeman, Laura E. Beane Sorensen, Karina Dalsgaard Orntoft, Torben Falck Borre, Michael Maehle, Lovise Grindedal, Eli Marie Neal, David E. Donovan, Jenny L. Hamdy, Freddie C. Martin, Richard M. Travis, Ruth C. Key, Tim J. Hamilton, Robert J. Fleshner, Neil E. Finelli, Antonio Ingles, Sue Ann Stern, Mariana C. Rosenstein, Barry Kerns, Sarah Ostrer, Harry Lu, Yong-Jie Zhang, Hong-Wei Feng, Ninghan Mao, Xueying Guo, Xin Wang, Guomin Sun, Zan Giles, Graham G. Southey, Melissa C. MacInnis, Robert J. FitzGerald, Liesel M. Kibel, Adam S. Drake, Bettina F. Vega, Ana Gómez-Caamaño, Antonio Fachal, Laura Szulkin, Robert Eklund, Martin Kogevinas, Manolis Llorca, Javier Castaño-Vinyals, Gemma Penney, Kathryn L. Stampfer, Meir Park, Jong Y. Sellers, Thomas A. Lin, Hui-Yi Stanford, Janet L. Cybulski, Cezary Wokolorczyk, Dominika Lubinski, Jan Ostrander, Elaine A. Geybels, Milan S. Nordestgaard, Børge G. Nielsen, Sune F. Weisher, Maren Bisbjerg, Rasmus Røder, Martin Andreas Iversen, Peter Brenner, Hermann Cuk, Katarina Holleczek, Bernd Maier, Christiane Luedeke, Manuel Schnoeller, Thomas Kim, Jeri Logothetis, Christopher J. John, Esther M. Teixeira, Manuel R. Paulo, Paula Cardoso, Marta Neuhausen, Susan L. Steele, Linda Ding, Yuan Chun De Ruyck, Kim De Meerleer, Gert Ost, Piet Razack, Azad Lim, Jasmine Teo, Soo-Hwang Lin, Daniel W. Newcomb, Lisa F. Lessel, Davor Gamulin, Marija Kulis, Tomislav Kaneva, Radka Usmani, Nawaid Slavov, Chavdar Mitev, Vanio Parliament, Matthew Singhal, Sandeep Claessens, Frank Joniau, Steven Van den Broeck, Thomas Larkin, Samantha Townsend, Paul A. Aukim-Hastie, Claire Gago-Dominguez, Manuela Castelao, Jose Esteban Martinez, Maria Elena Roobol, Monique J. Jenster, Guido van Schaik, Ron H. N. Menegaux, Florence Truong, Thérèse Koudou, Yves Akoli Xu, Jianfeng Khaw, Kay-Tee Cannon-Albright, Lisa Pandha, Hardev Michael, Agnieszka Kierzek, Andrzej Thibodeau, Stephen N. McDonnell, Shannon K. Schaid, Daniel J. Lindstrom, Sara Turman, Constance Ma, Jing Hunter, David J. Riboli, Elio Siddiq, Afshan Canzian, Federico Kolonel, Laurence N. Le Marchand, Loic Hoover, Robert N. Machiela, Mitchell J. Kraft, Peter Freedman, Matthew Wiklund, Fredrik Chanock, Stephen Henderson, Brian E. Easton, Douglas F. Haiman, Christopher A. Eeles, Rosalind A. Conti, David V. Kote-Jarai, Zsofia Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants |
title | Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants |
title_full | Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants |
title_fullStr | Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants |
title_full_unstemmed | Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants |
title_short | Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants |
title_sort | fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995836/ https://www.ncbi.nlm.nih.gov/pubmed/29892050 http://dx.doi.org/10.1038/s41467-018-04109-8 |
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finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT travisruthc finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT keytimj finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT hamiltonrobertj finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT fleshnerneile finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT finelliantonio finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT inglessueann finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT sternmarianac finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT rosensteinbarry finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT kernssarah finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT ostrerharry finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT luyongjie finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT zhanghongwei finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT fengninghan finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT maoxueying finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT guoxin finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT wangguomin finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT sunzan finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT gilesgrahamg finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT southeymelissac finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT macinnisrobertj finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT fitzgeraldlieselm finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT kibeladams finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT drakebettinaf finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT vegaana finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT gomezcaamanoantonio finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT fachallaura finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT szulkinrobert finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT eklundmartin finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT kogevinasmanolis finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT llorcajavier finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT castanovinyalsgemma finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT penneykathrynl finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT stampfermeir finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT parkjongy finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT sellersthomasa finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT linhuiyi finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT stanfordjanetl finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT cybulskicezary finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT wokolorczykdominika finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT lubinskijan finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT ostranderelainea finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT geybelsmilans finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT nordestgaardbørgeg finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT nielsensunef finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT weishermaren finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT bisbjergrasmus finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT rødermartinandreas finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT iversenpeter finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT brennerhermann finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT cukkatarina finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT holleczekbernd finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT maierchristiane finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT luedekemanuel finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT schnoellerthomas finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT kimjeri finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT logothetischristopherj finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT johnestherm finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT teixeiramanuelr finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT paulopaula finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT cardosomarta finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT neuhausensusanl finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT steelelinda finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT dingyuanchun finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT deruyckkim finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT demeerleergert finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT ostpiet finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT razackazad finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT limjasmine finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT teosoohwang finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT lindanielw finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT newcomblisaf finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT lesseldavor finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT gamulinmarija finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT kulistomislav finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT kanevaradka finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT usmaninawaid finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT slavovchavdar finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT mitevvanio finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT parliamentmatthew finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT singhalsandeep finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT claessensfrank finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT joniausteven finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT vandenbroeckthomas finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT larkinsamantha finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT townsendpaula finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT aukimhastieclaire finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT gagodominguezmanuela finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT castelaojoseesteban finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT martinezmariaelena finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT roobolmoniquej finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT jensterguido finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT vanschaikronhn finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT menegauxflorence finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT truongtherese finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT koudouyvesakoli finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT xujianfeng finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT khawkaytee finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT cannonalbrightlisa finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT pandhahardev finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT michaelagnieszka finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT kierzekandrzej finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT thibodeaustephenn finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT mcdonnellshannonk finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT schaiddanielj finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT lindstromsara finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT turmanconstance finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT majing finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT hunterdavidj finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT ribolielio finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT siddiqafshan finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT canzianfederico finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT kolonellaurencen finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT lemarchandloic finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT hooverrobertn finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT machielamitchellj finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT kraftpeter finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT freedmanmatthew finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT wiklundfredrik finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT chanockstephen finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT hendersonbriane finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT eastondouglasf finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT haimanchristophera finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT eelesrosalinda finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT contidavidv finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants AT kotejaraizsofia finemappingofprostatecancersusceptibilitylociinalargemetaanalysisidentifiescandidatecausalvariants |