Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds

Drug-induced liver injury (DILI) has become a major problem for patients and for clinicians, academics and the pharmaceutical industry. To date, existing hepatotoxicity test systems are only poorly predictive and the underlying mechanisms are still unclear. One of the factors known to amplify hepato...

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Detalles Bibliográficos
Autores principales: Oppelt, Angela, Kaschek, Daniel, Huppelschoten, Suzanna, Sison-Young, Rowena, Zhang, Fang, Buck-Wiese, Marie, Herrmann, Franziska, Malkusch, Sebastian, Krüger, Carmen L., Meub, Mara, Merkt, Benjamin, Zimmermann, Lea, Schofield, Amy, Jones, Robert P., Malik, Hassan, Schilling, Marcel, Heilemann, Mike, van de Water, Bob, Goldring, Christopher E., Park, B. Kevin, Timmer, Jens, Klingmüller, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995845/
https://www.ncbi.nlm.nih.gov/pubmed/29900006
http://dx.doi.org/10.1038/s41540-018-0058-z

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