Cargando…

(−)-Gochnatiolide B, synthesized from dehydrocostuslactone, exhibits potent anti-bladder cancer activity in vitro and in vivo

With limited success achieved in bladder cancer patient management, novel agents are in urgent need for the purpose of therapy and prevention. As a sesquiterpenoid dimmer isolated from Gochnatia pomculat, (−)-gochnatiolide B has been bio-mimetically synthesized in multiple steps with a poor yield, w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yuwen, Li, Wenhua, Zeng, Zhongqiu, Tang, Yaxiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995859/ https://www.ncbi.nlm.nih.gov/pubmed/29891980 http://dx.doi.org/10.1038/s41598-018-27036-6

Ejemplares similares

A dimeric sesquiterpene, gochnatiolide A
por: Xiong, Hui-Ping, et al.
Publicado: (2009)

Potential Anti-Cancer Activities and Mechanisms of Costunolide and Dehydrocostuslactone
por: Lin, Xuejing, et al.
Publicado: (2015)

Dehydrocostuslactone Suppresses Angiogenesis In Vitro and In Vivo through Inhibition of Akt/GSK-3β and mTOR Signaling Pathways
por: Wang, Chih-Ya, et al.
Publicado: (2012)

Inhibition of Inflammatory and Proliferative Responses of Human Keratinocytes Exposed to the Sesquiterpene Lactones Dehydrocostuslactone and Costunolide
por: Scarponi, Claudia, et al.
Publicado: (2014)

Sparsomycin Exhibits Potent Antiplasmodial Activity In Vitro and In Vivo
por: Ariefta, Nanang Rudianto, et al.
Publicado: (2022)

Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo
por: Kamkumo, Raceline G, et al.
Publicado: (2012)

Pectin lyase-modified red ginseng extract exhibits potent anti-glycation effects in vitro and in vivo
por: Kim, Chan-Sik, et al.
Publicado: (2017)

Two Naturally Occurring Terpenes, Dehydrocostuslactone and Costunolide, Decrease Intracellular GSH Content and Inhibit STAT3 Activation
por: Butturini, Elena, et al.
Publicado: (2011)

Trichlorobenzene-substituted azaaryl compounds as novel FGFR inhibitors exhibiting potent antitumor activity in bladder cancer cells in vitro and in vivo
por: Chen, Chun-Han, et al.
Publicado: (2016)

TPGS-1000 exhibits potent anticancer activity for hepatocellular carcinoma in vitro and in vivo
por: Chen, Yidan, et al.
Publicado: (2020)

Anti-cancer small molecule JP-8g exhibits potent in vivo anti-inflammatory activity
por: Sun, Yulong, et al.
Publicado: (2014)

Cetylpyridinium Chloride (CPC) Exhibits Potent, Rapid Activity Against Influenza Viruses in vitro and in vivo
por: Popkin, Daniel L., et al.
Publicado: (2017)

Novel Sophoridine Derivatives Bearing Phosphoramide Mustard Moiety Exhibit Potent Antitumor Activities In Vitro and In Vivo
por: Li, Dongdong, et al.
Publicado: (2018)

Potent in vitro and in vivo effects of polyclonal anti-human-myeloma globulins
por: Schieferdecker, Aneta, et al.
Publicado: (2016)

HbAHP-25, a peptide designed in silico, exhibits potent anti-HIV activity in vitro
por: Bashir, Tahir, et al.
Publicado: (2014)

NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia
por: Kowolik, Claudia M., et al.
Publicado: (2016)

L-Asparaginase Isolated from Phaseolus vulgaris Seeds Exhibited Potent Anti-Acute Lymphoblastic Leukemia Effects In-Vitro and Low Immunogenic Properties In-Vivo
por: Mohamed, Saleh A., et al.
Publicado: (2016)

L-4, a Well-Tolerated and Orally Active Inhibitor of Hedgehog Pathway, Exhibited Potent Anti-tumor Effects Against Medulloblastoma in vitro and in vivo
por: Zhu, Mingfei, et al.
Publicado: (2019)

Potent In Vitro and Ex Vivo Anti-Gonococcal Activity of the RpoB Inhibitor Corallopyronin A
por: Edwards, Jennifer L., et al.
Publicado: (2022)

A Poly-D-Mannose Synthesized by a One-Pot Method Exhibits Anti-Biofilm, Antioxidant, and Anti-Inflammatory Properties In Vitro
por: Tian, Dandan, et al.
Publicado: (2023)

CT-721, a Potent Bcr-Abl Inhibitor, Exhibits Excellent In Vitro and In Vivo Efficacy in the Treatment of Chronic Myeloid Leukemia
por: Sun, Yinghui, et al.
Publicado: (2017)

RAM, an RGDS Analog, Exerts Potent Anti-Melanoma Effects In Vitro and In Vivo
por: Aguzzi, Maria Simona, et al.
Publicado: (2011)

Hydroquinone Exhibits In Vitro and In Vivo Anti-Cancer Activity in Cancer Cells and Mice
por: Byeon, Se Eun, et al.
Publicado: (2018)

Sanguinarine exhibits potent efficacy against cervical cancer cells through inhibiting the STAT3 pathway in vitro and in vivo
por: Zhang, Huijuan, et al.
Publicado: (2019)

Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer
por: Sikander, Mohammed, et al.
Publicado: (2016)

Eupafolin Exhibits Potent Anti-Angiogenic and Antitumor Activity in Hepatocellular Carcinoma
por: Jiang, Honglei, et al.
Publicado: (2017)

Mosloflavone-Resveratrol Hybrid TMS-HDMF-5z Exhibits Potent In Vitro and In Vivo Anti-Inflammatory Effects Through NF-κB, AP-1, and JAK/STAT Inactivation
por: Kim, Seo-Yeon, et al.
Publicado: (2022)

Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway
por: Peng, Zhangxiao, et al.
Publicado: (2017)

In Vitro and In Vivo Trypanocidal Efficacy of Synthesized Nitrofurantoin Analogs
por: Munsimbwe, Linous, et al.
Publicado: (2021)

A glucose carbonate apatite complex exhibits in vitro and in vivo anti-tumour effects
por: Yamamoto, Hirofumi, et al.
Publicado: (2015)

Potent Antimalarial Activity of Acriflavine In Vitro and In Vivo
por: Dana, Srikanta, et al.
Publicado: (2014)

Nanocarrier Drug Conjugates Exhibit Potent Anti-Naegleria fowleri and Anti-Balamuthia mandrillaris Properties
por: Siddiqui, Ruqaiyyah, et al.
Publicado: (2023)

Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect
por: Xu, Haineng, et al.
Publicado: (2014)

In Vitro and In Vivo Anti-Breast Cancer Activities of Some Synthesized Pyrazolinyl-estran-17-one Candidates
por: Amr, Abd El-Galil E., et al.
Publicado: (2018)

Garlicnin B1, an Active Cyclic Sulfide from Garlic, Exhibits Potent Anti-Inflammatory and Anti-Tumor Activities
por: Gao, Shanghui, et al.
Publicado: (2023)

Hispidulin exhibits potent anticancer activity in vitro and in vivo through activating ER stress in non-small-cell lung cancer cells
por: Lv, Li, et al.
Publicado: (2020)

Ipatasertib exhibits anti-tumorigenic effects and enhances sensitivity to paclitaxel in endometrial cancer in vitro and in vivo
por: O'donnell, Jillian, et al.
Publicado: (2023)

RGD-modifided oncolytic adenovirus exhibited potent cytotoxic effect on CAR-negative bladder cancer-initiating cells
por: Yang, Y, et al.
Publicado: (2015)

Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo
por: Fakhrudin, N, et al.
Publicado: (2014)

A New Water‐soluble Camptothecin Derivative, DX‐8951f, Exhibits Potent Antitumor Activity against Human Tumors in vitro and in vivo
por: Mitsui, Ikuo, et al.
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_7bfnjpfqkke06lr31g7qnu08t3