Optimizing the Synthesis of Core/shell Structure Au@Cu(2)S Nanocrystals as Contrast-enhanced for Bioimaging Detection

In this paper, we reported Au@Cu(2)S nanocrystals in the aqueous phase with a core/shell structure and dBSA encapsulation. The dBSA-Au@Cu(2)S crystals formed with an average size of approximately 9 nm. There was a strong absorption in the near-infrared (NIR) field located at 1348 nm, and they exhibi...

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Autores principales: Liu, Liwei, Hu, Siyi, Wang, Yue, Yang, Shaozhuang, Qu, Junle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995884/
https://www.ncbi.nlm.nih.gov/pubmed/29891943
http://dx.doi.org/10.1038/s41598-018-27015-x
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author Liu, Liwei
Hu, Siyi
Wang, Yue
Yang, Shaozhuang
Qu, Junle
author_facet Liu, Liwei
Hu, Siyi
Wang, Yue
Yang, Shaozhuang
Qu, Junle
author_sort Liu, Liwei
collection PubMed
description In this paper, we reported Au@Cu(2)S nanocrystals in the aqueous phase with a core/shell structure and dBSA encapsulation. The dBSA-Au@Cu(2)S crystals formed with an average size of approximately 9 nm. There was a strong absorption in the near-infrared (NIR) field located at 1348 nm, and they exhibited low toxicity in the in vitro tests. Furthermore, we demonstrated that dBSA-Au@Cu(2)S could be used for optical coherence tomography (OCT). The in vivo experimental results show that the OCT signal increased as the concentration of nanocrystals increased. In this research, we revealed that these core/shell-structured nanocrystals along with their low toxicity and excellent biocompatibility could be a valuable tool for current and future contrast-enhanced in vivo studies.
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spelling pubmed-59958842018-06-21 Optimizing the Synthesis of Core/shell Structure Au@Cu(2)S Nanocrystals as Contrast-enhanced for Bioimaging Detection Liu, Liwei Hu, Siyi Wang, Yue Yang, Shaozhuang Qu, Junle Sci Rep Article In this paper, we reported Au@Cu(2)S nanocrystals in the aqueous phase with a core/shell structure and dBSA encapsulation. The dBSA-Au@Cu(2)S crystals formed with an average size of approximately 9 nm. There was a strong absorption in the near-infrared (NIR) field located at 1348 nm, and they exhibited low toxicity in the in vitro tests. Furthermore, we demonstrated that dBSA-Au@Cu(2)S could be used for optical coherence tomography (OCT). The in vivo experimental results show that the OCT signal increased as the concentration of nanocrystals increased. In this research, we revealed that these core/shell-structured nanocrystals along with their low toxicity and excellent biocompatibility could be a valuable tool for current and future contrast-enhanced in vivo studies. Nature Publishing Group UK 2018-06-11 /pmc/articles/PMC5995884/ /pubmed/29891943 http://dx.doi.org/10.1038/s41598-018-27015-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Liu, Liwei
Hu, Siyi
Wang, Yue
Yang, Shaozhuang
Qu, Junle
Optimizing the Synthesis of Core/shell Structure Au@Cu(2)S Nanocrystals as Contrast-enhanced for Bioimaging Detection
title Optimizing the Synthesis of Core/shell Structure Au@Cu(2)S Nanocrystals as Contrast-enhanced for Bioimaging Detection
title_full Optimizing the Synthesis of Core/shell Structure Au@Cu(2)S Nanocrystals as Contrast-enhanced for Bioimaging Detection
title_fullStr Optimizing the Synthesis of Core/shell Structure Au@Cu(2)S Nanocrystals as Contrast-enhanced for Bioimaging Detection
title_full_unstemmed Optimizing the Synthesis of Core/shell Structure Au@Cu(2)S Nanocrystals as Contrast-enhanced for Bioimaging Detection
title_short Optimizing the Synthesis of Core/shell Structure Au@Cu(2)S Nanocrystals as Contrast-enhanced for Bioimaging Detection
title_sort optimizing the synthesis of core/shell structure au@cu(2)s nanocrystals as contrast-enhanced for bioimaging detection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995884/
https://www.ncbi.nlm.nih.gov/pubmed/29891943
http://dx.doi.org/10.1038/s41598-018-27015-x
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