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An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex
Aberrant activation of RAS signalling pathways contributes to aggressive phenotypes of cancer cells. The RAS-targeted therapies for cancer, therefore, have been recognised to be effective; however, current developments on targeting RAS have not advanced due to structural features of the RAS protein....
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995912/ https://www.ncbi.nlm.nih.gov/pubmed/29891945 http://dx.doi.org/10.1038/s41467-018-04771-y |