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Potent block of potassium channels by MEK inhibitor U0126 in primary cultures and brain slices

U0126 (1,4-diamino-2,3-dicyano-1,4-bis (2-aminophenylthio) butadiene), a widely used mitogen-activated protein kinase kinase (MEK) inhibitor, was found to accelerate voltage-gated K(+) channel (K(V)) inactivation in heterologous cells expressing several types of K(V). The goal of this study was to e...

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Detalles Bibliográficos
Autores principales:	Wang, Jin-Zhao, Long, Cheng, Li, Kai-Yuan, Xu, Hua-Tai, Yuan, Li-Lian, Wu, Gang-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995919/ https://www.ncbi.nlm.nih.gov/pubmed/29892075 http://dx.doi.org/10.1038/s41598-018-27235-1

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