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Sensory dominance and multisensory integration as screening tools in aging

Multisensory information typically confers neural and behavioural advantages over unisensory information. We used a simple audio-visual detection task to compare healthy young (HY), healthy older (HO) and mild-cognitive impairment (MCI) individuals. Neuropsychological tests assessed individuals’ lea...

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Autores principales: Murray, Micah M., Eardley, Alison F., Edginton, Trudi, Oyekan, Rebecca, Smyth, Emily, Matusz, Pawel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995929/
https://www.ncbi.nlm.nih.gov/pubmed/29891964
http://dx.doi.org/10.1038/s41598-018-27288-2
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author Murray, Micah M.
Eardley, Alison F.
Edginton, Trudi
Oyekan, Rebecca
Smyth, Emily
Matusz, Pawel J.
author_facet Murray, Micah M.
Eardley, Alison F.
Edginton, Trudi
Oyekan, Rebecca
Smyth, Emily
Matusz, Pawel J.
author_sort Murray, Micah M.
collection PubMed
description Multisensory information typically confers neural and behavioural advantages over unisensory information. We used a simple audio-visual detection task to compare healthy young (HY), healthy older (HO) and mild-cognitive impairment (MCI) individuals. Neuropsychological tests assessed individuals’ learning and memory impairments. First, we provide much-needed clarification regarding the presence of enhanced multisensory benefits in both healthily and abnormally aging individuals. The pattern of sensory dominance shifted with healthy and abnormal aging to favour a propensity of auditory-dominant behaviour (i.e., detecting sounds faster than flashes). Notably, multisensory benefits were larger only in healthy older than younger individuals who were also visually-dominant. Second, we demonstrate that the multisensory detection task offers benefits as a time- and resource-economic MCI screening tool. Receiver operating characteristic (ROC) analysis demonstrated that MCI diagnosis could be reliably achieved based on the combination of indices of multisensory integration together with indices of sensory dominance. Our findings showcase the importance of sensory profiles in determining multisensory benefits in healthy and abnormal aging. Crucially, our findings open an exciting possibility for multisensory detection tasks to be used as a cost-effective screening tool. These findings clarify relationships between multisensory and memory functions in aging, while offering new avenues for improved dementia diagnostics.
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spelling pubmed-59959292018-06-21 Sensory dominance and multisensory integration as screening tools in aging Murray, Micah M. Eardley, Alison F. Edginton, Trudi Oyekan, Rebecca Smyth, Emily Matusz, Pawel J. Sci Rep Article Multisensory information typically confers neural and behavioural advantages over unisensory information. We used a simple audio-visual detection task to compare healthy young (HY), healthy older (HO) and mild-cognitive impairment (MCI) individuals. Neuropsychological tests assessed individuals’ learning and memory impairments. First, we provide much-needed clarification regarding the presence of enhanced multisensory benefits in both healthily and abnormally aging individuals. The pattern of sensory dominance shifted with healthy and abnormal aging to favour a propensity of auditory-dominant behaviour (i.e., detecting sounds faster than flashes). Notably, multisensory benefits were larger only in healthy older than younger individuals who were also visually-dominant. Second, we demonstrate that the multisensory detection task offers benefits as a time- and resource-economic MCI screening tool. Receiver operating characteristic (ROC) analysis demonstrated that MCI diagnosis could be reliably achieved based on the combination of indices of multisensory integration together with indices of sensory dominance. Our findings showcase the importance of sensory profiles in determining multisensory benefits in healthy and abnormal aging. Crucially, our findings open an exciting possibility for multisensory detection tasks to be used as a cost-effective screening tool. These findings clarify relationships between multisensory and memory functions in aging, while offering new avenues for improved dementia diagnostics. Nature Publishing Group UK 2018-06-11 /pmc/articles/PMC5995929/ /pubmed/29891964 http://dx.doi.org/10.1038/s41598-018-27288-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Murray, Micah M.
Eardley, Alison F.
Edginton, Trudi
Oyekan, Rebecca
Smyth, Emily
Matusz, Pawel J.
Sensory dominance and multisensory integration as screening tools in aging
title Sensory dominance and multisensory integration as screening tools in aging
title_full Sensory dominance and multisensory integration as screening tools in aging
title_fullStr Sensory dominance and multisensory integration as screening tools in aging
title_full_unstemmed Sensory dominance and multisensory integration as screening tools in aging
title_short Sensory dominance and multisensory integration as screening tools in aging
title_sort sensory dominance and multisensory integration as screening tools in aging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995929/
https://www.ncbi.nlm.nih.gov/pubmed/29891964
http://dx.doi.org/10.1038/s41598-018-27288-2
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