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Involvement of non-coding RNAs in chemotherapy resistance of ovarian cancer

Ovarian cancer (OC) is the most lethal gynecological malignancy, with a low 5-year survival rate. Most patients with ovarian cancer are diagnosed in late-stages. A rising number of non-coding RNAs (ncRNAs) have been found to act as key regulators of gene expression by applying novel high-thought met...

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Autores principales: Shao, Yang, Li, Hui, Du, Ran, Meng, Jiao, Yang, Gong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995945/
https://www.ncbi.nlm.nih.gov/pubmed/29896281
http://dx.doi.org/10.7150/jca.24550
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author Shao, Yang
Li, Hui
Du, Ran
Meng, Jiao
Yang, Gong
author_facet Shao, Yang
Li, Hui
Du, Ran
Meng, Jiao
Yang, Gong
author_sort Shao, Yang
collection PubMed
description Ovarian cancer (OC) is the most lethal gynecological malignancy, with a low 5-year survival rate. Most patients with ovarian cancer are diagnosed in late-stages. A rising number of non-coding RNAs (ncRNAs) have been found to act as key regulators of gene expression by applying novel high-thought methods, such as next generation sequencing (NGS). Non-coding RNAs not only play important roles in carcinogenesis, but also affect the clinical treatment strategies. One of the biggest challenge in OC treatment was chemoresistance, which causes poor prognosis and high recurrence rate after applying traditional remedies. Of note, it has been proved that ncRNAs were deeply correlated with chemoresistance in several cancers, which made ncRNAs considered to be potential therapeutic targets in ovarian cancer. Among of all ncRNAs, the studies of miRNAs and lncRNAs in ovarian cancer chemoresistance were much clearer. In this study, we reviewed the most relevant researches in this field, and described the relationships between ncRNAs and chemoresistance in ovarian cancer.
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spelling pubmed-59959452018-06-12 Involvement of non-coding RNAs in chemotherapy resistance of ovarian cancer Shao, Yang Li, Hui Du, Ran Meng, Jiao Yang, Gong J Cancer Review Ovarian cancer (OC) is the most lethal gynecological malignancy, with a low 5-year survival rate. Most patients with ovarian cancer are diagnosed in late-stages. A rising number of non-coding RNAs (ncRNAs) have been found to act as key regulators of gene expression by applying novel high-thought methods, such as next generation sequencing (NGS). Non-coding RNAs not only play important roles in carcinogenesis, but also affect the clinical treatment strategies. One of the biggest challenge in OC treatment was chemoresistance, which causes poor prognosis and high recurrence rate after applying traditional remedies. Of note, it has been proved that ncRNAs were deeply correlated with chemoresistance in several cancers, which made ncRNAs considered to be potential therapeutic targets in ovarian cancer. Among of all ncRNAs, the studies of miRNAs and lncRNAs in ovarian cancer chemoresistance were much clearer. In this study, we reviewed the most relevant researches in this field, and described the relationships between ncRNAs and chemoresistance in ovarian cancer. Ivyspring International Publisher 2018-04-30 /pmc/articles/PMC5995945/ /pubmed/29896281 http://dx.doi.org/10.7150/jca.24550 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Shao, Yang
Li, Hui
Du, Ran
Meng, Jiao
Yang, Gong
Involvement of non-coding RNAs in chemotherapy resistance of ovarian cancer
title Involvement of non-coding RNAs in chemotherapy resistance of ovarian cancer
title_full Involvement of non-coding RNAs in chemotherapy resistance of ovarian cancer
title_fullStr Involvement of non-coding RNAs in chemotherapy resistance of ovarian cancer
title_full_unstemmed Involvement of non-coding RNAs in chemotherapy resistance of ovarian cancer
title_short Involvement of non-coding RNAs in chemotherapy resistance of ovarian cancer
title_sort involvement of non-coding rnas in chemotherapy resistance of ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995945/
https://www.ncbi.nlm.nih.gov/pubmed/29896281
http://dx.doi.org/10.7150/jca.24550
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