Modular cell-internalizing aptamer nanostructure enables targeted delivery of large functional RNAs in cancer cell lines

Large RNAs and ribonucleoprotein complexes have powerful therapeutic potential, but effective cell-targeted delivery tools are limited. Aptamers that internalize into target cells can deliver siRNAs (<15 kDa, 19–21 nt/strand). We demonstrate a modular nanostructure for cellular delivery of large,...

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Detalles Bibliográficos
Autores principales: Porciani, David, Cardwell, Leah N., Tawiah, Kwaku D., Alam, Khalid K., Lange, Margaret J., Daniels, Mark A., Burke, Donald H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995956/
https://www.ncbi.nlm.nih.gov/pubmed/29891903
http://dx.doi.org/10.1038/s41467-018-04691-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995956/
https://www.ncbi.nlm.nih.gov/pubmed/29891903
http://dx.doi.org/10.1038/s41467-018-04691-x

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