AKT signalling selectively regulates PINK1 mitophagy in SHSY5Y cells and human iPSC-derived neurons

The discovery of mutations within genes associated with autosomal recessive Parkinson’s disease allowed for the identification of PINK1/Parkin regulated mitophagy as an important pathway for the removal of damaged mitochondria. While recent studies suggest that AKT-dependent signalling regulates Par...

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Detalles Bibliográficos
Autores principales: Soutar, Marc P. M., Kempthorne, Liam, Miyakawa, Shuichi, Annuario, Emily, Melandri, Daniela, Harley, Jasmine, O’Sullivan, Gregory A., Wray, Selina, Hancock, David C., Cookson, Mark R., Downward, Julian, Carlton, Mark, Plun-Favreau, Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995958/
https://www.ncbi.nlm.nih.gov/pubmed/29891871
http://dx.doi.org/10.1038/s41598-018-26949-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995958/
https://www.ncbi.nlm.nih.gov/pubmed/29891871
http://dx.doi.org/10.1038/s41598-018-26949-6

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