Cargando…

Autophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention

Traumatic brain injury (TBI) is one of the most devastating forms of brain injury. Many pathological mechanisms such as oxidative stress, apoptosis and inflammation all contribute to the secondary brain damage and poor outcomes of TBI. Current therapies are often ineffective and poorly tolerated, wh...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Li, Wang, Handong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996030/
https://www.ncbi.nlm.nih.gov/pubmed/29922127
http://dx.doi.org/10.3389/fnmol.2018.00190
_version_ 1783330740115603456
author Zhang, Li
Wang, Handong
author_facet Zhang, Li
Wang, Handong
author_sort Zhang, Li
collection PubMed
description Traumatic brain injury (TBI) is one of the most devastating forms of brain injury. Many pathological mechanisms such as oxidative stress, apoptosis and inflammation all contribute to the secondary brain damage and poor outcomes of TBI. Current therapies are often ineffective and poorly tolerated, which drive the explore of new therapeutic targets for TBI. Autophagy is a highly conserved intracellular mechanism during evolution. It plays an important role in elimination abnormal intracellular proteins or organelles to maintain cell stability. Besides, autophagy has been researched in various models including TBI. Previous studies have deciphered that regulation of autophagy by different molecules and pathways could exhibit anti-oxidative stress, anti-apoptosis and anti-inflammation effects in TBI. Hence, autophagy is a promising target for further therapeutic development in TBI. The present review provides an overview of current knowledge about the mechanism of autophagy, the frequently used methods to monitor autophagy, the functions of autophagy in TBI as well as its potential molecular mechanisms based on the pharmacological regulation of autophagy.
format Online
Article
Text
id pubmed-5996030
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-59960302018-06-19 Autophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention Zhang, Li Wang, Handong Front Mol Neurosci Neuroscience Traumatic brain injury (TBI) is one of the most devastating forms of brain injury. Many pathological mechanisms such as oxidative stress, apoptosis and inflammation all contribute to the secondary brain damage and poor outcomes of TBI. Current therapies are often ineffective and poorly tolerated, which drive the explore of new therapeutic targets for TBI. Autophagy is a highly conserved intracellular mechanism during evolution. It plays an important role in elimination abnormal intracellular proteins or organelles to maintain cell stability. Besides, autophagy has been researched in various models including TBI. Previous studies have deciphered that regulation of autophagy by different molecules and pathways could exhibit anti-oxidative stress, anti-apoptosis and anti-inflammation effects in TBI. Hence, autophagy is a promising target for further therapeutic development in TBI. The present review provides an overview of current knowledge about the mechanism of autophagy, the frequently used methods to monitor autophagy, the functions of autophagy in TBI as well as its potential molecular mechanisms based on the pharmacological regulation of autophagy. Frontiers Media S.A. 2018-06-05 /pmc/articles/PMC5996030/ /pubmed/29922127 http://dx.doi.org/10.3389/fnmol.2018.00190 Text en Copyright © 2018 Zhang and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhang, Li
Wang, Handong
Autophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention
title Autophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention
title_full Autophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention
title_fullStr Autophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention
title_full_unstemmed Autophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention
title_short Autophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention
title_sort autophagy in traumatic brain injury: a new target for therapeutic intervention
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996030/
https://www.ncbi.nlm.nih.gov/pubmed/29922127
http://dx.doi.org/10.3389/fnmol.2018.00190
work_keys_str_mv AT zhangli autophagyintraumaticbraininjuryanewtargetfortherapeuticintervention
AT wanghandong autophagyintraumaticbraininjuryanewtargetfortherapeuticintervention