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Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates
The formation of new neurons in the adult central nervous system (CNS) has been recognized as one of the major findings in neuroanatomical research. The hippocampal formation (HF), one of the main targets of these investigations, holds a neurogenic niche widely recognized among several mammalian spe...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996050/ https://www.ncbi.nlm.nih.gov/pubmed/29922131 http://dx.doi.org/10.3389/fnana.2018.00044 |
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author | Baptista, Pedro Andrade, José P. |
author_facet | Baptista, Pedro Andrade, José P. |
author_sort | Baptista, Pedro |
collection | PubMed |
description | The formation of new neurons in the adult central nervous system (CNS) has been recognized as one of the major findings in neuroanatomical research. The hippocampal formation (HF), one of the main targets of these investigations, holds a neurogenic niche widely recognized among several mammalian species and whose existence in the human brain has sparked controversy and extensive debate. Many cellular features from this region emphasize that hippocampal neurogenesis suffers changes with normal aging and, among regulatory factors, physical exercise and chronic stress provoke opposite effects on cell proliferation, maturation and survival. Considering the numerous functions attributable to the HF, increasing or decreasing the integration of new neurons in the delicate neuronal network might be significant for modulation of cognition and emotion. The role that immature and mature adult-born neurons play in this circuitry is still mostly unknown but it could prove fundamental to understand hippocampal-dependent cognitive processes, the pathophysiology of depression, and the therapeutic effects of antidepressant medication in modulating behavior and mental health. |
format | Online Article Text |
id | pubmed-5996050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59960502018-06-19 Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates Baptista, Pedro Andrade, José P. Front Neuroanat Neuroscience The formation of new neurons in the adult central nervous system (CNS) has been recognized as one of the major findings in neuroanatomical research. The hippocampal formation (HF), one of the main targets of these investigations, holds a neurogenic niche widely recognized among several mammalian species and whose existence in the human brain has sparked controversy and extensive debate. Many cellular features from this region emphasize that hippocampal neurogenesis suffers changes with normal aging and, among regulatory factors, physical exercise and chronic stress provoke opposite effects on cell proliferation, maturation and survival. Considering the numerous functions attributable to the HF, increasing or decreasing the integration of new neurons in the delicate neuronal network might be significant for modulation of cognition and emotion. The role that immature and mature adult-born neurons play in this circuitry is still mostly unknown but it could prove fundamental to understand hippocampal-dependent cognitive processes, the pathophysiology of depression, and the therapeutic effects of antidepressant medication in modulating behavior and mental health. Frontiers Media S.A. 2018-06-05 /pmc/articles/PMC5996050/ /pubmed/29922131 http://dx.doi.org/10.3389/fnana.2018.00044 Text en Copyright © 2018 Baptista and Andrade. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Baptista, Pedro Andrade, José P. Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates |
title | Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates |
title_full | Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates |
title_fullStr | Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates |
title_full_unstemmed | Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates |
title_short | Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates |
title_sort | adult hippocampal neurogenesis: regulation and possible functional and clinical correlates |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996050/ https://www.ncbi.nlm.nih.gov/pubmed/29922131 http://dx.doi.org/10.3389/fnana.2018.00044 |
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