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Vesicle-Mediated Control of Cell Function: The Role of Extracellular Matrix and Microenvironment

Extracellular vesicles (EVs) — including exosomes, microvesicles and apoptotic bodies — have received much scientific attention last decade as mediators of a newly discovered cell-to-cell communication system, acting at short and long distances. EVs carry biologically active molecules, thus providin...

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Autores principales: Rackov, Gorjana, Garcia-Romero, Noemi, Esteban-Rubio, Susana, Carrión-Navarro, Josefa, Belda-Iniesta, Cristobal, Ayuso-Sacido, Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996101/
https://www.ncbi.nlm.nih.gov/pubmed/29922170
http://dx.doi.org/10.3389/fphys.2018.00651
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author Rackov, Gorjana
Garcia-Romero, Noemi
Esteban-Rubio, Susana
Carrión-Navarro, Josefa
Belda-Iniesta, Cristobal
Ayuso-Sacido, Angel
author_facet Rackov, Gorjana
Garcia-Romero, Noemi
Esteban-Rubio, Susana
Carrión-Navarro, Josefa
Belda-Iniesta, Cristobal
Ayuso-Sacido, Angel
author_sort Rackov, Gorjana
collection PubMed
description Extracellular vesicles (EVs) — including exosomes, microvesicles and apoptotic bodies — have received much scientific attention last decade as mediators of a newly discovered cell-to-cell communication system, acting at short and long distances. EVs carry biologically active molecules, thus providing signals that influence a spectrum of functions in recipient cells during various physiological and pathological processes. Recent findings point to EVs as very attractive immunomodulatory therapeutic agents, vehicles for drug delivery and diagnostic and prognostic biomarkers in liquid biopsies. In addition, EVs interact with and regulate the synthesis of extracellular matrix (ECM) components, which is crucial for organ development and wound healing, as well as bone and cardiovascular calcification. EVs carrying matrix metalloproteinases (MMPs) are involved in ECM remodeling, thus modifying tumor microenvironment and contributing to premetastatic niche formation and angiogenesis. Here we review the role of EVs in control of cell function, with emphasis on their interaction with ECM and microenvironment in health and disease.
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spelling pubmed-59961012018-06-19 Vesicle-Mediated Control of Cell Function: The Role of Extracellular Matrix and Microenvironment Rackov, Gorjana Garcia-Romero, Noemi Esteban-Rubio, Susana Carrión-Navarro, Josefa Belda-Iniesta, Cristobal Ayuso-Sacido, Angel Front Physiol Physiology Extracellular vesicles (EVs) — including exosomes, microvesicles and apoptotic bodies — have received much scientific attention last decade as mediators of a newly discovered cell-to-cell communication system, acting at short and long distances. EVs carry biologically active molecules, thus providing signals that influence a spectrum of functions in recipient cells during various physiological and pathological processes. Recent findings point to EVs as very attractive immunomodulatory therapeutic agents, vehicles for drug delivery and diagnostic and prognostic biomarkers in liquid biopsies. In addition, EVs interact with and regulate the synthesis of extracellular matrix (ECM) components, which is crucial for organ development and wound healing, as well as bone and cardiovascular calcification. EVs carrying matrix metalloproteinases (MMPs) are involved in ECM remodeling, thus modifying tumor microenvironment and contributing to premetastatic niche formation and angiogenesis. Here we review the role of EVs in control of cell function, with emphasis on their interaction with ECM and microenvironment in health and disease. Frontiers Media S.A. 2018-06-05 /pmc/articles/PMC5996101/ /pubmed/29922170 http://dx.doi.org/10.3389/fphys.2018.00651 Text en Copyright © 2018 Rackov, Garcia-Romero, Esteban-Rubio, Carrión-Navarro, Belda-Iniesta and Ayuso-Sacido. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Rackov, Gorjana
Garcia-Romero, Noemi
Esteban-Rubio, Susana
Carrión-Navarro, Josefa
Belda-Iniesta, Cristobal
Ayuso-Sacido, Angel
Vesicle-Mediated Control of Cell Function: The Role of Extracellular Matrix and Microenvironment
title Vesicle-Mediated Control of Cell Function: The Role of Extracellular Matrix and Microenvironment
title_full Vesicle-Mediated Control of Cell Function: The Role of Extracellular Matrix and Microenvironment
title_fullStr Vesicle-Mediated Control of Cell Function: The Role of Extracellular Matrix and Microenvironment
title_full_unstemmed Vesicle-Mediated Control of Cell Function: The Role of Extracellular Matrix and Microenvironment
title_short Vesicle-Mediated Control of Cell Function: The Role of Extracellular Matrix and Microenvironment
title_sort vesicle-mediated control of cell function: the role of extracellular matrix and microenvironment
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996101/
https://www.ncbi.nlm.nih.gov/pubmed/29922170
http://dx.doi.org/10.3389/fphys.2018.00651
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