Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases

The term “tissue kallikrein” is used to describe a group of serine proteases shared considerable sequence homology and colocalize in the same chromosomal locus 19q13. 2–q13.4. It has been widely discovered in various tissues and has been proved to be involved in kinds of pathophysiological processes...

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Autores principales: Wei, Zhenyu, Lyu, Yi, Yang, XiaoLi, Chen, Xin, Zhong, Ping, Wu, Danhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996104/
https://www.ncbi.nlm.nih.gov/pubmed/29922218
http://dx.doi.org/10.3389/fneur.2018.00403
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author Wei, Zhenyu
Lyu, Yi
Yang, XiaoLi
Chen, Xin
Zhong, Ping
Wu, Danhong
author_facet Wei, Zhenyu
Lyu, Yi
Yang, XiaoLi
Chen, Xin
Zhong, Ping
Wu, Danhong
author_sort Wei, Zhenyu
collection PubMed
description The term “tissue kallikrein” is used to describe a group of serine proteases shared considerable sequence homology and colocalize in the same chromosomal locus 19q13. 2–q13.4. It has been widely discovered in various tissues and has been proved to be involved in kinds of pathophysiological processes, such as inhibiting oxidative stress, inflammation, apoptosis, fibrosis and promoting angiogenesis, and neurogenesis. Human Urinary Kallidinogenase (HUK) extracted from human urine is a member of tissue kallikrein which could convert kininogen to kinin and hence improve the plasma kinin level. Medical value of HUK has been widely investigated in China, especially on acute ischemic stroke. In this review, we will summarize the therapeutic values of Human Urinary Kallidinogenase on acute ischemic stroke and its potential mechanisms.
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spelling pubmed-59961042018-06-19 Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases Wei, Zhenyu Lyu, Yi Yang, XiaoLi Chen, Xin Zhong, Ping Wu, Danhong Front Neurol Neurology The term “tissue kallikrein” is used to describe a group of serine proteases shared considerable sequence homology and colocalize in the same chromosomal locus 19q13. 2–q13.4. It has been widely discovered in various tissues and has been proved to be involved in kinds of pathophysiological processes, such as inhibiting oxidative stress, inflammation, apoptosis, fibrosis and promoting angiogenesis, and neurogenesis. Human Urinary Kallidinogenase (HUK) extracted from human urine is a member of tissue kallikrein which could convert kininogen to kinin and hence improve the plasma kinin level. Medical value of HUK has been widely investigated in China, especially on acute ischemic stroke. In this review, we will summarize the therapeutic values of Human Urinary Kallidinogenase on acute ischemic stroke and its potential mechanisms. Frontiers Media S.A. 2018-06-05 /pmc/articles/PMC5996104/ /pubmed/29922218 http://dx.doi.org/10.3389/fneur.2018.00403 Text en Copyright © 2018 Wei, Lyu, Yang, Chen, Zhong and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Wei, Zhenyu
Lyu, Yi
Yang, XiaoLi
Chen, Xin
Zhong, Ping
Wu, Danhong
Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases
title Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases
title_full Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases
title_fullStr Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases
title_full_unstemmed Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases
title_short Therapeutic Values of Human Urinary Kallidinogenase on Cerebrovascular Diseases
title_sort therapeutic values of human urinary kallidinogenase on cerebrovascular diseases
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996104/
https://www.ncbi.nlm.nih.gov/pubmed/29922218
http://dx.doi.org/10.3389/fneur.2018.00403
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