Data set on G4 DNA interactions with human proteins

Guanine-rich DNA/RNA fragments can fold into G-quadruplexes (G4s) – non-canonical four-strand secondary structures. The article contains data on quadruplex interaction with human proteins. Binding of three topologically different G4 structures to more than 9000 human proteins was analyzed. Physicoch...

Descripción completa

Detalles Bibliográficos
Autores principales: Vlasenok, M., Levchenko, O., Basmanov, D., Klinov, D., Varizhuk, A., Pozmogova, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Genetics, Genomics and Molecular Biology   
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996148/
https://www.ncbi.nlm.nih.gov/pubmed/29896522
http://dx.doi.org/10.1016/j.dib.2018.02.081
_version_ 1783330777102024704
author Vlasenok, M.
Levchenko, O.
Basmanov, D.
Klinov, D.
Varizhuk, A.
Pozmogova, G.
author_facet Vlasenok, M.
Levchenko, O.
Basmanov, D.
Klinov, D.
Varizhuk, A.
Pozmogova, G.
author_sort Vlasenok, M.
collection PubMed
description Guanine-rich DNA/RNA fragments can fold into G-quadruplexes (G4s) – non-canonical four-strand secondary structures. The article contains data on quadruplex interaction with human proteins. Binding of three topologically different G4 structures to more than 9000 human proteins was analyzed. Physicochemical methods were used to verify the results.The dataset was generated to identify the protein targets for DNA quadruplex structures for the purpose of better understanding the role of the structures in gene expression regulation. Presented data include functional interpretation of obtained gene lists, visualized with Cytoscape.
format Online
Article
Text
id pubmed-5996148
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-59961482018-06-12 Data set on G4 DNA interactions with human proteins Vlasenok, M. Levchenko, O. Basmanov, D. Klinov, D. Varizhuk, A. Pozmogova, G. Data Brief Genetics, Genomics and Molecular Biology    Guanine-rich DNA/RNA fragments can fold into G-quadruplexes (G4s) – non-canonical four-strand secondary structures. The article contains data on quadruplex interaction with human proteins. Binding of three topologically different G4 structures to more than 9000 human proteins was analyzed. Physicochemical methods were used to verify the results.The dataset was generated to identify the protein targets for DNA quadruplex structures for the purpose of better understanding the role of the structures in gene expression regulation. Presented data include functional interpretation of obtained gene lists, visualized with Cytoscape. Elsevier 2018-03-09 /pmc/articles/PMC5996148/ /pubmed/29896522 http://dx.doi.org/10.1016/j.dib.2018.02.081 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Genetics, Genomics and Molecular Biology   
Vlasenok, M.
Levchenko, O.
Basmanov, D.
Klinov, D.
Varizhuk, A.
Pozmogova, G.
Data set on G4 DNA interactions with human proteins
title Data set on G4 DNA interactions with human proteins
title_full Data set on G4 DNA interactions with human proteins
title_fullStr Data set on G4 DNA interactions with human proteins
title_full_unstemmed Data set on G4 DNA interactions with human proteins
title_short Data set on G4 DNA interactions with human proteins
title_sort data set on g4 dna interactions with human proteins
topic Genetics, Genomics and Molecular Biology   
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996148/
https://www.ncbi.nlm.nih.gov/pubmed/29896522
http://dx.doi.org/10.1016/j.dib.2018.02.081
work_keys_str_mv AT vlasenokm datasetong4dnainteractionswithhumanproteins
AT levchenkoo datasetong4dnainteractionswithhumanproteins
AT basmanovd datasetong4dnainteractionswithhumanproteins
AT klinovd datasetong4dnainteractionswithhumanproteins
AT varizhuka datasetong4dnainteractionswithhumanproteins
AT pozmogovag datasetong4dnainteractionswithhumanproteins

Ejemplares similares