Data on the expression of CXCR3 ligands and pro-inflammatory cytokines in macrophages and CD4(+) T cells after stimuli of CXCR3 ligands

C-X-C motif chemokine receptor 3 (CXCR3) is a G protein-coupled receptor for three ligands which are C-X-C motif chemokine 9 (CXCL9), CXCL10, and CXCL11 [1]. Previously we have reported that CXCL10 promotes pro-inflammatory cytokine expression, and forms positive feedback loop [2], [3]. In the prese...

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Detalles Bibliográficos
Autores principales: Kim, Bongjun, Lee, Jong-Ho, Jin, Won Jong, Kim, Hong-Hee, Ha, Hyunil, Lee, Zang Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Cell biology   
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996269/
https://www.ncbi.nlm.nih.gov/pubmed/29900211
http://dx.doi.org/10.1016/j.dib.2018.03.042
Descripción
Sumario:C-X-C motif chemokine receptor 3 (CXCR3) is a G protein-coupled receptor for three ligands which are C-X-C motif chemokine 9 (CXCL9), CXCL10, and CXCL11 [1]. Previously we have reported that CXCL10 promotes pro-inflammatory cytokine expression, and forms positive feedback loop [2], [3]. In the present study, we described mRNA expression of CXCL9 and CXCL11 under CXCL10 stimuli in the presence or absence of CXCR3 antagonist, JN-2 in bone marrow-derived macrophages (BMMs) and CD4(+) T cells. In addition, we examined pro-inflammatory cytokine expression under CXCL9 or CXCL11 stimuli in BMMs and CD4(+) T cells.

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