Increased Reactive Oxygen Species and Cell Cycle Defects Contribute to Anemia in the RASA3 Mutant Mouse Model scat

RASA3 is a Ras GTPase activating protein that plays a critical role in blood formation. The autosomal recessive mouse model scat (severe combined anemia and thrombocytopenia) carries a missense mutation in Rasa3. Homozygotes present with a phenotype characteristic of bone marrow failure that is acco...

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Detalles Bibliográficos
Autores principales: Hartman, Emily S., Brindley, Elena C., Papoin, Julien, Ciciotte, Steven L., Zhao, Yue, Peters, Luanne L., Blanc, Lionel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996270/
https://www.ncbi.nlm.nih.gov/pubmed/29922180
http://dx.doi.org/10.3389/fphys.2018.00689

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