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Long Chain n-3 Fatty Acids Improve Depression Syndrome in Type 2 Diabetes Mellitus
BACKGROUND: Type 2 diabetes mellitus (T2DM) is commonly associated with depressive symptoms, which affect prognosis and quality of life. We investigated the antidepressant effects of n-3 fatty acids (n-3FAs) monotherapy (without conventional antidepressants) for T2DM patients with mild to moderate d...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996325/ https://www.ncbi.nlm.nih.gov/pubmed/29900143 |
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author | MAZAHERIOUN, Maryam SAEDISOMEOLIA, Ahmad JAVANBAKHT, Mohammad Hassan KOOHDANI, Fariba ZAREI, Mahnaz ANSARI, Samaneh KHOSHKHOO BAZARGANI, Fatemeh DJALALI, Mahmoud |
author_facet | MAZAHERIOUN, Maryam SAEDISOMEOLIA, Ahmad JAVANBAKHT, Mohammad Hassan KOOHDANI, Fariba ZAREI, Mahnaz ANSARI, Samaneh KHOSHKHOO BAZARGANI, Fatemeh DJALALI, Mahmoud |
author_sort | MAZAHERIOUN, Maryam |
collection | PubMed |
description | BACKGROUND: Type 2 diabetes mellitus (T2DM) is commonly associated with depressive symptoms, which affect prognosis and quality of life. We investigated the antidepressant effects of n-3 fatty acids (n-3FAs) monotherapy (without conventional antidepressants) for T2DM patients with mild to moderate depressive symptoms. METHODS: A 10-wk, placebo-controlled, double-blind, parallel-group (1:1 ratio) randomized trial of n-3FAs (2700 mg/day EPA: DHA ratio=2) versus placebo in 88 Iranian diabetic patients with mild to moderate depression based on Beck Depression Inventory II (BDI-II-PERSIAN) was conducted. This study started from July 2014 to January 2015 in Tehran University of Medical Sciences, Tehran, Iran. The primary event was defined as worsened, non-changed, or inconsiderably improved depression (<5 unit decrease in BDI-II-PERSIAN depression scores after treatment) (ClinicalTrials.gov Identifier: NCT02261545). RESULTS: Randomly, 44 T2DM patients were treated with n-3FAs supplements and 44 cases received placebo (three patients discontinued). n-3FAs could significantly protect patients against the aforesaid event and exhibit satisfactory prevention (number needed to treat with 95% confidence interval: 2.52, 1.71–4.74). No serious adverse reactions were reported. CONCLUSION: n-3FAs supplementation had significant antidepressant effects in T2DM patients with mild to moderate depressive symptoms, not confounded by metabolic factors and disease duration. |
format | Online Article Text |
id | pubmed-5996325 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-59963252018-06-13 Long Chain n-3 Fatty Acids Improve Depression Syndrome in Type 2 Diabetes Mellitus MAZAHERIOUN, Maryam SAEDISOMEOLIA, Ahmad JAVANBAKHT, Mohammad Hassan KOOHDANI, Fariba ZAREI, Mahnaz ANSARI, Samaneh KHOSHKHOO BAZARGANI, Fatemeh DJALALI, Mahmoud Iran J Public Health Original Article BACKGROUND: Type 2 diabetes mellitus (T2DM) is commonly associated with depressive symptoms, which affect prognosis and quality of life. We investigated the antidepressant effects of n-3 fatty acids (n-3FAs) monotherapy (without conventional antidepressants) for T2DM patients with mild to moderate depressive symptoms. METHODS: A 10-wk, placebo-controlled, double-blind, parallel-group (1:1 ratio) randomized trial of n-3FAs (2700 mg/day EPA: DHA ratio=2) versus placebo in 88 Iranian diabetic patients with mild to moderate depression based on Beck Depression Inventory II (BDI-II-PERSIAN) was conducted. This study started from July 2014 to January 2015 in Tehran University of Medical Sciences, Tehran, Iran. The primary event was defined as worsened, non-changed, or inconsiderably improved depression (<5 unit decrease in BDI-II-PERSIAN depression scores after treatment) (ClinicalTrials.gov Identifier: NCT02261545). RESULTS: Randomly, 44 T2DM patients were treated with n-3FAs supplements and 44 cases received placebo (three patients discontinued). n-3FAs could significantly protect patients against the aforesaid event and exhibit satisfactory prevention (number needed to treat with 95% confidence interval: 2.52, 1.71–4.74). No serious adverse reactions were reported. CONCLUSION: n-3FAs supplementation had significant antidepressant effects in T2DM patients with mild to moderate depressive symptoms, not confounded by metabolic factors and disease duration. Tehran University of Medical Sciences 2018-04 /pmc/articles/PMC5996325/ /pubmed/29900143 Text en Copyright© Iranian Public Health Association & Tehran University of Medical Sciences http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article MAZAHERIOUN, Maryam SAEDISOMEOLIA, Ahmad JAVANBAKHT, Mohammad Hassan KOOHDANI, Fariba ZAREI, Mahnaz ANSARI, Samaneh KHOSHKHOO BAZARGANI, Fatemeh DJALALI, Mahmoud Long Chain n-3 Fatty Acids Improve Depression Syndrome in Type 2 Diabetes Mellitus |
title | Long Chain n-3 Fatty Acids Improve Depression Syndrome in Type 2 Diabetes Mellitus |
title_full | Long Chain n-3 Fatty Acids Improve Depression Syndrome in Type 2 Diabetes Mellitus |
title_fullStr | Long Chain n-3 Fatty Acids Improve Depression Syndrome in Type 2 Diabetes Mellitus |
title_full_unstemmed | Long Chain n-3 Fatty Acids Improve Depression Syndrome in Type 2 Diabetes Mellitus |
title_short | Long Chain n-3 Fatty Acids Improve Depression Syndrome in Type 2 Diabetes Mellitus |
title_sort | long chain n-3 fatty acids improve depression syndrome in type 2 diabetes mellitus |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996325/ https://www.ncbi.nlm.nih.gov/pubmed/29900143 |
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