Cargando…

Efficacy and Safety of Vitamin D Supplementation for Pulmonary Tuberculosis: A Systematic Review and Meta-analysis

BACKGROUND: Vitamin D might be promising to serve as an adjunctive therapy for pulmonary tuberculosis (TB). However, the results remained controversial. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of vitamin D in patients with pulmonary TB. METHODS: Medline...

Descripción completa

Detalles Bibliográficos
Autores principales: WANG, Ji, FENG, Malong, YING, Shidong, ZHOU, Jianfang, LI, Xiaoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996342/
https://www.ncbi.nlm.nih.gov/pubmed/29900130
_version_ 1783330834612224000
author WANG, Ji
FENG, Malong
YING, Shidong
ZHOU, Jianfang
LI, Xiaoqing
author_facet WANG, Ji
FENG, Malong
YING, Shidong
ZHOU, Jianfang
LI, Xiaoqing
author_sort WANG, Ji
collection PubMed
description BACKGROUND: Vitamin D might be promising to serve as an adjunctive therapy for pulmonary tuberculosis (TB). However, the results remained controversial. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of vitamin D in patients with pulmonary TB. METHODS: Medline, SCOPUS, Google Scholar, EMBASE, Springer, and Science Direct were searched electronically from inception to Oct 2016. Randomized controlled trials (RCTs) and controlled clinical trials (CCTs) assessing the effect of vitamin D plus anti-tuberculosis treatment (ATT) versus placebo plus ATT on the treatment of pulmonary TB were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. Data were analyzed using RevMan 5.3 software. RESULTS: Five studies were included in this meta-analysis. Overall, compared with placebo intervention, vitamin D supplementation was found to have no significant effect on sputum smear negative conversion rates (RR=0.99; 95% CI=0.91 to 1.07; P=0.77), BMI (MD=0.11; 95% CI=−0.85 to 1.07; P=0.82) and ESR (MD=−2.29; 95% CI=−8.87 to 4.30; P=0.50). CONCLUSION: Vitamin D supplementation showed no influence on the improvement of sputum smear-negative conversion rates and BMI, as well as the decrease in ESR.
format Online
Article
Text
id pubmed-5996342
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Tehran University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-59963422018-06-13 Efficacy and Safety of Vitamin D Supplementation for Pulmonary Tuberculosis: A Systematic Review and Meta-analysis WANG, Ji FENG, Malong YING, Shidong ZHOU, Jianfang LI, Xiaoqing Iran J Public Health Review Article BACKGROUND: Vitamin D might be promising to serve as an adjunctive therapy for pulmonary tuberculosis (TB). However, the results remained controversial. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of vitamin D in patients with pulmonary TB. METHODS: Medline, SCOPUS, Google Scholar, EMBASE, Springer, and Science Direct were searched electronically from inception to Oct 2016. Randomized controlled trials (RCTs) and controlled clinical trials (CCTs) assessing the effect of vitamin D plus anti-tuberculosis treatment (ATT) versus placebo plus ATT on the treatment of pulmonary TB were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies. Data were analyzed using RevMan 5.3 software. RESULTS: Five studies were included in this meta-analysis. Overall, compared with placebo intervention, vitamin D supplementation was found to have no significant effect on sputum smear negative conversion rates (RR=0.99; 95% CI=0.91 to 1.07; P=0.77), BMI (MD=0.11; 95% CI=−0.85 to 1.07; P=0.82) and ESR (MD=−2.29; 95% CI=−8.87 to 4.30; P=0.50). CONCLUSION: Vitamin D supplementation showed no influence on the improvement of sputum smear-negative conversion rates and BMI, as well as the decrease in ESR. Tehran University of Medical Sciences 2018-04 /pmc/articles/PMC5996342/ /pubmed/29900130 Text en Copyright© Iranian Public Health Association & Tehran University of Medical Sciences http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
WANG, Ji
FENG, Malong
YING, Shidong
ZHOU, Jianfang
LI, Xiaoqing
Efficacy and Safety of Vitamin D Supplementation for Pulmonary Tuberculosis: A Systematic Review and Meta-analysis
title Efficacy and Safety of Vitamin D Supplementation for Pulmonary Tuberculosis: A Systematic Review and Meta-analysis
title_full Efficacy and Safety of Vitamin D Supplementation for Pulmonary Tuberculosis: A Systematic Review and Meta-analysis
title_fullStr Efficacy and Safety of Vitamin D Supplementation for Pulmonary Tuberculosis: A Systematic Review and Meta-analysis
title_full_unstemmed Efficacy and Safety of Vitamin D Supplementation for Pulmonary Tuberculosis: A Systematic Review and Meta-analysis
title_short Efficacy and Safety of Vitamin D Supplementation for Pulmonary Tuberculosis: A Systematic Review and Meta-analysis
title_sort efficacy and safety of vitamin d supplementation for pulmonary tuberculosis: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996342/
https://www.ncbi.nlm.nih.gov/pubmed/29900130
work_keys_str_mv AT wangji efficacyandsafetyofvitamindsupplementationforpulmonarytuberculosisasystematicreviewandmetaanalysis
AT fengmalong efficacyandsafetyofvitamindsupplementationforpulmonarytuberculosisasystematicreviewandmetaanalysis
AT yingshidong efficacyandsafetyofvitamindsupplementationforpulmonarytuberculosisasystematicreviewandmetaanalysis
AT zhoujianfang efficacyandsafetyofvitamindsupplementationforpulmonarytuberculosisasystematicreviewandmetaanalysis
AT lixiaoqing efficacyandsafetyofvitamindsupplementationforpulmonarytuberculosisasystematicreviewandmetaanalysis