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Modifier locus mapping of a transgenic F2 mouse population identifies CCDC115 as a novel aggressive prostate cancer modifier gene in humans

BACKGROUND: It is well known that development of prostate cancer (PC) can be attributed to somatic mutations of the genome, acquired within proto-oncogenes or tumor-suppressor genes. What is less well understood is how germline variation contributes to disease aggressiveness in PC patients. To map g...

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Detalles Bibliográficos
Autores principales:	Winter, Jean M., Curry, Natasha L., Gildea, Derek M., Williams, Kendra A., Lee, Minnkyong, Hu, Ying, Crawford, Nigel P. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996485/ https://www.ncbi.nlm.nih.gov/pubmed/29890952 http://dx.doi.org/10.1186/s12864-018-4827-2

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