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Takayasu’s arteritis associated with eosinophilic gastroenteritis, possibly via the overactivation of Th17
BACKGROUND: Takayasu’s arteritis (TA) is a large-vessel vasculitis pathologically characterized by granulomatous necrotizing vasculitis with giant cells. Although the cause of TA is still unclear, genetic factors as well as immunological abnormalities, particularly the overactivation of Th1 and Th-1...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996549/ https://www.ncbi.nlm.nih.gov/pubmed/29942355 http://dx.doi.org/10.1186/s13099-018-0251-z |
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author | Fujiya, Mikihiro Kashima, Shin Sugiyama, Yuya Iwama, Takuya Ijiri, Masami Tanaka, Kazuyuki Takahashi, Keitaro Ando, Katuyoshi Nomura, Yoshiki Ueno, Nobuhiro Goto, Takuma Moriichi, Kentaro Mizukami, Yusuke Okumura, Toshikatsu Sasajima, Junpei Fujishiro, Daisuke Okamoto, Kensaku Makino, Yuichi |
author_facet | Fujiya, Mikihiro Kashima, Shin Sugiyama, Yuya Iwama, Takuya Ijiri, Masami Tanaka, Kazuyuki Takahashi, Keitaro Ando, Katuyoshi Nomura, Yoshiki Ueno, Nobuhiro Goto, Takuma Moriichi, Kentaro Mizukami, Yusuke Okumura, Toshikatsu Sasajima, Junpei Fujishiro, Daisuke Okamoto, Kensaku Makino, Yuichi |
author_sort | Fujiya, Mikihiro |
collection | PubMed |
description | BACKGROUND: Takayasu’s arteritis (TA) is a large-vessel vasculitis pathologically characterized by granulomatous necrotizing vasculitis with giant cells. Although the cause of TA is still unclear, genetic factors as well as immunological abnormalities, particularly the overactivation of Th1 and Th-17, are considered to play important roles in the pathogenesis of this disease. Eosinophilic gastroenteritis (EGE) is a type of refractory inflammation in which numerous eosinophils infiltrate the inflammatory area. It is known that the overactivation of Th2 is associated with the pathogenesis of EGE, although the cause of EGE is still unclear. The immunological abnormalities in TA are therefore thought to be different from those in EGE. To date, no cases of complication of TA and EGE have been reported. CASE PRESENTATIONS: An 18 year-old female was diagnosed with EGE and treated with prednisolone. At 6 months after completion of the treatment, the patient experienced chest pain, and was diagnosed with TA. TH1 and TH17 immunity are thought to be involved with TA, while TH2 are considered to be involved with EGE. In this case, the expression of IL-17 mRNA in the colon mucosa greatly decreased after prednisolone treatment for EGE. CONCLUSIONS: This is the first report of TA complicated with EGE, and the overactivation of TH17 is considered to be associated with the pathogenesis of these two diseases. |
format | Online Article Text |
id | pubmed-5996549 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-59965492018-06-25 Takayasu’s arteritis associated with eosinophilic gastroenteritis, possibly via the overactivation of Th17 Fujiya, Mikihiro Kashima, Shin Sugiyama, Yuya Iwama, Takuya Ijiri, Masami Tanaka, Kazuyuki Takahashi, Keitaro Ando, Katuyoshi Nomura, Yoshiki Ueno, Nobuhiro Goto, Takuma Moriichi, Kentaro Mizukami, Yusuke Okumura, Toshikatsu Sasajima, Junpei Fujishiro, Daisuke Okamoto, Kensaku Makino, Yuichi Gut Pathog Case Report BACKGROUND: Takayasu’s arteritis (TA) is a large-vessel vasculitis pathologically characterized by granulomatous necrotizing vasculitis with giant cells. Although the cause of TA is still unclear, genetic factors as well as immunological abnormalities, particularly the overactivation of Th1 and Th-17, are considered to play important roles in the pathogenesis of this disease. Eosinophilic gastroenteritis (EGE) is a type of refractory inflammation in which numerous eosinophils infiltrate the inflammatory area. It is known that the overactivation of Th2 is associated with the pathogenesis of EGE, although the cause of EGE is still unclear. The immunological abnormalities in TA are therefore thought to be different from those in EGE. To date, no cases of complication of TA and EGE have been reported. CASE PRESENTATIONS: An 18 year-old female was diagnosed with EGE and treated with prednisolone. At 6 months after completion of the treatment, the patient experienced chest pain, and was diagnosed with TA. TH1 and TH17 immunity are thought to be involved with TA, while TH2 are considered to be involved with EGE. In this case, the expression of IL-17 mRNA in the colon mucosa greatly decreased after prednisolone treatment for EGE. CONCLUSIONS: This is the first report of TA complicated with EGE, and the overactivation of TH17 is considered to be associated with the pathogenesis of these two diseases. BioMed Central 2018-06-12 /pmc/articles/PMC5996549/ /pubmed/29942355 http://dx.doi.org/10.1186/s13099-018-0251-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Fujiya, Mikihiro Kashima, Shin Sugiyama, Yuya Iwama, Takuya Ijiri, Masami Tanaka, Kazuyuki Takahashi, Keitaro Ando, Katuyoshi Nomura, Yoshiki Ueno, Nobuhiro Goto, Takuma Moriichi, Kentaro Mizukami, Yusuke Okumura, Toshikatsu Sasajima, Junpei Fujishiro, Daisuke Okamoto, Kensaku Makino, Yuichi Takayasu’s arteritis associated with eosinophilic gastroenteritis, possibly via the overactivation of Th17 |
title | Takayasu’s arteritis associated with eosinophilic gastroenteritis, possibly via the overactivation of Th17 |
title_full | Takayasu’s arteritis associated with eosinophilic gastroenteritis, possibly via the overactivation of Th17 |
title_fullStr | Takayasu’s arteritis associated with eosinophilic gastroenteritis, possibly via the overactivation of Th17 |
title_full_unstemmed | Takayasu’s arteritis associated with eosinophilic gastroenteritis, possibly via the overactivation of Th17 |
title_short | Takayasu’s arteritis associated with eosinophilic gastroenteritis, possibly via the overactivation of Th17 |
title_sort | takayasu’s arteritis associated with eosinophilic gastroenteritis, possibly via the overactivation of th17 |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996549/ https://www.ncbi.nlm.nih.gov/pubmed/29942355 http://dx.doi.org/10.1186/s13099-018-0251-z |
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