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Supplementary data for the biological age linked to oxidative stress modifies breast cancer aggressiveness
The data presented in this article are related to the research paper entitled “The biological age linked to oxidative stress modifies breast cancer aggressiveness” (M.M. Sáez-Freire, A. Blanco-Gómez, S. Castillo-Lluva, A. Gómez-Vecino, J.M. Galvis-Jiménez, C. Martín-Seisdedos, M. Isidoro-García, L....
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996612/ https://www.ncbi.nlm.nih.gov/pubmed/29900291 http://dx.doi.org/10.1016/j.dib.2018.03.132 |
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author | Sáez-Freire, María del Mar Blanco-Gómez, Adrián Castillo-Lluva, Sonia Gómez-Vecino, Aurora Galvis-Jiménez, Julie Milena Martín-Seisdedos, Carmen Isidoro-García, María Hontecillas-Prieto, Lourdes García-Cenador, María Begoña García-Criado, Francisco Javier Patino-Alonso, María Carmen Galindo-Villardón, Purificación Mao, Jian-Hua Prieto, Carlos Castellanos-Martín, Andrés Kaderali, Lars Pérez-Losada, Jesús |
author_facet | Sáez-Freire, María del Mar Blanco-Gómez, Adrián Castillo-Lluva, Sonia Gómez-Vecino, Aurora Galvis-Jiménez, Julie Milena Martín-Seisdedos, Carmen Isidoro-García, María Hontecillas-Prieto, Lourdes García-Cenador, María Begoña García-Criado, Francisco Javier Patino-Alonso, María Carmen Galindo-Villardón, Purificación Mao, Jian-Hua Prieto, Carlos Castellanos-Martín, Andrés Kaderali, Lars Pérez-Losada, Jesús |
author_sort | Sáez-Freire, María del Mar |
collection | PubMed |
description | The data presented in this article are related to the research paper entitled “The biological age linked to oxidative stress modifies breast cancer aggressiveness” (M.M. Sáez-Freire, A. Blanco-Gómez, S. Castillo-Lluva, A. Gómez-Vecino, J.M. Galvis-Jiménez, C. Martín-Seisdedos, M. Isidoro-García, L. Hontecillas-Prieto, M.B. García-Cenador, F.J. García-Criado, M.C. Patino-Alonso, P. Galindo-Villardón, J.H. Mao, C. Prieto, A. Castellanos-Martín, L. Kaderali, J. Pérez-Losada). The data shown were obtained from a population of transgenic mice, MMTV-Erbb2/Neu, with different susceptibility to breast cancer and a mixed genetic background generated by backcrossing. It was observed that the aggressiveness of breast cancer negatively correlates with age, being lower in chronologically old mice, similar to what occurs in humans. Given that oxidative stress is associated with tumour susceptibility and the degree of aging, the association between the aggressiveness of breast cancer and multiple intermediate phenotypes directly or indirectly related to oxidative stress was studied. Using a mathematical model, we defined biological age and the degree of aging as the difference between biological and chronological ages. As a result, we observed that biologically old mice predominated among those that developed the disease early on, that is, those that were chronologically young. We then identified the specific and common genetic components of Quantitative Trait loci or QTL associated with different evolution of breast cancer, the intermediate phenotypes related to oxidative stress studied, the biological age and the degree of aging. Lastly, we showed that the expression pattern in the livers of biologically old mice were enriched in signalling pathways related to inflammation and response to infections; whereas the biologically young mice exhibited enriched pathways related to mitochondrial activity. For the explanation and discussion of these data refer to the research article cited above. |
format | Online Article Text |
id | pubmed-5996612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-59966122018-06-13 Supplementary data for the biological age linked to oxidative stress modifies breast cancer aggressiveness Sáez-Freire, María del Mar Blanco-Gómez, Adrián Castillo-Lluva, Sonia Gómez-Vecino, Aurora Galvis-Jiménez, Julie Milena Martín-Seisdedos, Carmen Isidoro-García, María Hontecillas-Prieto, Lourdes García-Cenador, María Begoña García-Criado, Francisco Javier Patino-Alonso, María Carmen Galindo-Villardón, Purificación Mao, Jian-Hua Prieto, Carlos Castellanos-Martín, Andrés Kaderali, Lars Pérez-Losada, Jesús Data Brief Medicine and Dentistry The data presented in this article are related to the research paper entitled “The biological age linked to oxidative stress modifies breast cancer aggressiveness” (M.M. Sáez-Freire, A. Blanco-Gómez, S. Castillo-Lluva, A. Gómez-Vecino, J.M. Galvis-Jiménez, C. Martín-Seisdedos, M. Isidoro-García, L. Hontecillas-Prieto, M.B. García-Cenador, F.J. García-Criado, M.C. Patino-Alonso, P. Galindo-Villardón, J.H. Mao, C. Prieto, A. Castellanos-Martín, L. Kaderali, J. Pérez-Losada). The data shown were obtained from a population of transgenic mice, MMTV-Erbb2/Neu, with different susceptibility to breast cancer and a mixed genetic background generated by backcrossing. It was observed that the aggressiveness of breast cancer negatively correlates with age, being lower in chronologically old mice, similar to what occurs in humans. Given that oxidative stress is associated with tumour susceptibility and the degree of aging, the association between the aggressiveness of breast cancer and multiple intermediate phenotypes directly or indirectly related to oxidative stress was studied. Using a mathematical model, we defined biological age and the degree of aging as the difference between biological and chronological ages. As a result, we observed that biologically old mice predominated among those that developed the disease early on, that is, those that were chronologically young. We then identified the specific and common genetic components of Quantitative Trait loci or QTL associated with different evolution of breast cancer, the intermediate phenotypes related to oxidative stress studied, the biological age and the degree of aging. Lastly, we showed that the expression pattern in the livers of biologically old mice were enriched in signalling pathways related to inflammation and response to infections; whereas the biologically young mice exhibited enriched pathways related to mitochondrial activity. For the explanation and discussion of these data refer to the research article cited above. Elsevier 2018-04-03 /pmc/articles/PMC5996612/ /pubmed/29900291 http://dx.doi.org/10.1016/j.dib.2018.03.132 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Medicine and Dentistry Sáez-Freire, María del Mar Blanco-Gómez, Adrián Castillo-Lluva, Sonia Gómez-Vecino, Aurora Galvis-Jiménez, Julie Milena Martín-Seisdedos, Carmen Isidoro-García, María Hontecillas-Prieto, Lourdes García-Cenador, María Begoña García-Criado, Francisco Javier Patino-Alonso, María Carmen Galindo-Villardón, Purificación Mao, Jian-Hua Prieto, Carlos Castellanos-Martín, Andrés Kaderali, Lars Pérez-Losada, Jesús Supplementary data for the biological age linked to oxidative stress modifies breast cancer aggressiveness |
title | Supplementary data for the biological age linked to oxidative stress modifies breast cancer aggressiveness |
title_full | Supplementary data for the biological age linked to oxidative stress modifies breast cancer aggressiveness |
title_fullStr | Supplementary data for the biological age linked to oxidative stress modifies breast cancer aggressiveness |
title_full_unstemmed | Supplementary data for the biological age linked to oxidative stress modifies breast cancer aggressiveness |
title_short | Supplementary data for the biological age linked to oxidative stress modifies breast cancer aggressiveness |
title_sort | supplementary data for the biological age linked to oxidative stress modifies breast cancer aggressiveness |
topic | Medicine and Dentistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996612/ https://www.ncbi.nlm.nih.gov/pubmed/29900291 http://dx.doi.org/10.1016/j.dib.2018.03.132 |
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