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Retinol Levels in Serum and Chronic Skin Lesions of Atopic Dermatitis

BACKGROUND: Atopic dermatitis (AD) is a common childhood dermatosis and a distressing cause of morbidity. The pathogenesis of AD is known to be associated with disorders of immune response and defect in antioxidant defense, genetic predisposition, environmental triggers, psychosomatic factors, and o...

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Autores principales: Biswas, Rabindranath, Chakraborti, Goutam, Mukherjee, Kheya, Bhattacharjee, Debojyoti, Mallick, Sabyasachi, Biswas, Tanmoy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996635/
https://www.ncbi.nlm.nih.gov/pubmed/29937563
http://dx.doi.org/10.4103/ijd.IJD_763_16
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author Biswas, Rabindranath
Chakraborti, Goutam
Mukherjee, Kheya
Bhattacharjee, Debojyoti
Mallick, Sabyasachi
Biswas, Tanmoy
author_facet Biswas, Rabindranath
Chakraborti, Goutam
Mukherjee, Kheya
Bhattacharjee, Debojyoti
Mallick, Sabyasachi
Biswas, Tanmoy
author_sort Biswas, Rabindranath
collection PubMed
description BACKGROUND: Atopic dermatitis (AD) is a common childhood dermatosis and a distressing cause of morbidity. The pathogenesis of AD is known to be associated with disorders of immune response and defect in antioxidant defense, genetic predisposition, environmental triggers, psychosomatic factors, and other mechanisms. Retinol has immunomodulatory and antioxidant effects, thus may have a protective role in AD. OBJECTIVE: The objective of this study was to evaluate the correlation of retinol levels in skin lesions and serum, with AD. MATERIALS AND METHODS: The study was a hospital-based, case–control study. Punch biopsy from the skin and venous blood of 86 participants (including 43 cases and 43 controls) were assayed for retinol levels by a reversed-phase high-performance liquid chromatography method. Analysis of data was performed using appropriate statistical methods. RESULTS: Skin and serum retinol levels were highly significantly decreased in patients in respect to that of controls. CONCLUSION: Retinol levels were decreased in AD. Retinol estimation may be used as a promising parameter for the elaboration of treatment strategy and monitoring.
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spelling pubmed-59966352018-06-22 Retinol Levels in Serum and Chronic Skin Lesions of Atopic Dermatitis Biswas, Rabindranath Chakraborti, Goutam Mukherjee, Kheya Bhattacharjee, Debojyoti Mallick, Sabyasachi Biswas, Tanmoy Indian J Dermatol Original Article BACKGROUND: Atopic dermatitis (AD) is a common childhood dermatosis and a distressing cause of morbidity. The pathogenesis of AD is known to be associated with disorders of immune response and defect in antioxidant defense, genetic predisposition, environmental triggers, psychosomatic factors, and other mechanisms. Retinol has immunomodulatory and antioxidant effects, thus may have a protective role in AD. OBJECTIVE: The objective of this study was to evaluate the correlation of retinol levels in skin lesions and serum, with AD. MATERIALS AND METHODS: The study was a hospital-based, case–control study. Punch biopsy from the skin and venous blood of 86 participants (including 43 cases and 43 controls) were assayed for retinol levels by a reversed-phase high-performance liquid chromatography method. Analysis of data was performed using appropriate statistical methods. RESULTS: Skin and serum retinol levels were highly significantly decreased in patients in respect to that of controls. CONCLUSION: Retinol levels were decreased in AD. Retinol estimation may be used as a promising parameter for the elaboration of treatment strategy and monitoring. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5996635/ /pubmed/29937563 http://dx.doi.org/10.4103/ijd.IJD_763_16 Text en Copyright: © 2018 Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Biswas, Rabindranath
Chakraborti, Goutam
Mukherjee, Kheya
Bhattacharjee, Debojyoti
Mallick, Sabyasachi
Biswas, Tanmoy
Retinol Levels in Serum and Chronic Skin Lesions of Atopic Dermatitis
title Retinol Levels in Serum and Chronic Skin Lesions of Atopic Dermatitis
title_full Retinol Levels in Serum and Chronic Skin Lesions of Atopic Dermatitis
title_fullStr Retinol Levels in Serum and Chronic Skin Lesions of Atopic Dermatitis
title_full_unstemmed Retinol Levels in Serum and Chronic Skin Lesions of Atopic Dermatitis
title_short Retinol Levels in Serum and Chronic Skin Lesions of Atopic Dermatitis
title_sort retinol levels in serum and chronic skin lesions of atopic dermatitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996635/
https://www.ncbi.nlm.nih.gov/pubmed/29937563
http://dx.doi.org/10.4103/ijd.IJD_763_16
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