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Correlation of CD133 and Oct-4 expression with clinicopathological and demographic parameters in oral squamous cell carcinoma patients

OBJECTIVE: Squamous cell carcinoma of oral cavity is one of the most common cancers of Indian subcontinent with the 5-year survival rate of 50% despite the recent advances in the treatment. The aim of the present study was to study cancer stem cell markers CD133 and Oct-4 in oral squamous cell carci...

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Autores principales: Singh, Alok, Srivastava, Anand Narain, Akhtar, Salman, Siddiqui, Mohammad Haris, Singh, Pooja, Kumar, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996651/
https://www.ncbi.nlm.nih.gov/pubmed/29937653
http://dx.doi.org/10.4103/njms.NJMS_60_17
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author Singh, Alok
Srivastava, Anand Narain
Akhtar, Salman
Siddiqui, Mohammad Haris
Singh, Pooja
Kumar, Vijay
author_facet Singh, Alok
Srivastava, Anand Narain
Akhtar, Salman
Siddiqui, Mohammad Haris
Singh, Pooja
Kumar, Vijay
author_sort Singh, Alok
collection PubMed
description OBJECTIVE: Squamous cell carcinoma of oral cavity is one of the most common cancers of Indian subcontinent with the 5-year survival rate of 50% despite the recent advances in the treatment. The aim of the present study was to study cancer stem cell markers CD133 and Oct-4 in oral squamous cell carcinoma (OSCC) patients and their correlation with clinicopathological variables. MATERIALS AND METHODS: This was a prospective study which included 50 cases of histopathologically proven squamous cell carcinoma of oral cavity. Expression of CD133 and Oct-4 was evaluated by immunohistochemistry (IHC) and their expression was correlated with various clinicopathological and demographic parameters. RESULTS: CD133 expression was seen in 20.6% cases of clinical Stage I–II and in 79.4% of clinical stage of III-IV OSCC patients, the difference being statistically significant with the P = 0.048. There was no statistically significant association between CD133 expression and any other clinicopathological or demographic variable. Oct-4 was expressed only in one case. CONCLUSIONS: CD133 expression was significantly seen higher in Stage III–IV tumors, the stem cells may be responsible for the aggressiveness of the OSCCs and these stem cells can be potential prognostic markers and targets for the future targeted therapy.
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spelling pubmed-59966512018-06-22 Correlation of CD133 and Oct-4 expression with clinicopathological and demographic parameters in oral squamous cell carcinoma patients Singh, Alok Srivastava, Anand Narain Akhtar, Salman Siddiqui, Mohammad Haris Singh, Pooja Kumar, Vijay Natl J Maxillofac Surg Original Article OBJECTIVE: Squamous cell carcinoma of oral cavity is one of the most common cancers of Indian subcontinent with the 5-year survival rate of 50% despite the recent advances in the treatment. The aim of the present study was to study cancer stem cell markers CD133 and Oct-4 in oral squamous cell carcinoma (OSCC) patients and their correlation with clinicopathological variables. MATERIALS AND METHODS: This was a prospective study which included 50 cases of histopathologically proven squamous cell carcinoma of oral cavity. Expression of CD133 and Oct-4 was evaluated by immunohistochemistry (IHC) and their expression was correlated with various clinicopathological and demographic parameters. RESULTS: CD133 expression was seen in 20.6% cases of clinical Stage I–II and in 79.4% of clinical stage of III-IV OSCC patients, the difference being statistically significant with the P = 0.048. There was no statistically significant association between CD133 expression and any other clinicopathological or demographic variable. Oct-4 was expressed only in one case. CONCLUSIONS: CD133 expression was significantly seen higher in Stage III–IV tumors, the stem cells may be responsible for the aggressiveness of the OSCCs and these stem cells can be potential prognostic markers and targets for the future targeted therapy. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5996651/ /pubmed/29937653 http://dx.doi.org/10.4103/njms.NJMS_60_17 Text en Copyright: © 2018 National Journal of Maxillofacial Surgery http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Singh, Alok
Srivastava, Anand Narain
Akhtar, Salman
Siddiqui, Mohammad Haris
Singh, Pooja
Kumar, Vijay
Correlation of CD133 and Oct-4 expression with clinicopathological and demographic parameters in oral squamous cell carcinoma patients
title Correlation of CD133 and Oct-4 expression with clinicopathological and demographic parameters in oral squamous cell carcinoma patients
title_full Correlation of CD133 and Oct-4 expression with clinicopathological and demographic parameters in oral squamous cell carcinoma patients
title_fullStr Correlation of CD133 and Oct-4 expression with clinicopathological and demographic parameters in oral squamous cell carcinoma patients
title_full_unstemmed Correlation of CD133 and Oct-4 expression with clinicopathological and demographic parameters in oral squamous cell carcinoma patients
title_short Correlation of CD133 and Oct-4 expression with clinicopathological and demographic parameters in oral squamous cell carcinoma patients
title_sort correlation of cd133 and oct-4 expression with clinicopathological and demographic parameters in oral squamous cell carcinoma patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996651/
https://www.ncbi.nlm.nih.gov/pubmed/29937653
http://dx.doi.org/10.4103/njms.NJMS_60_17
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