Cargando…

Analysis on the association between sperm DNA fragmentation index and conventional semen parameters, blood microelements and seminal plasma ROS in male patients with infertility

We conducted this study to analyze the sperm DNA fragmentation index, conventional semen parameters, blood microelements and seminal plasma reactive oxygen species (ROS) in patients with male infertility to determine the association between each of the above male physiological parameters and DNA fra...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Deng'e, Lu, Chen, Zhu, Ying, Zhu, Sulan, Yang, Er-Jiang, Jin, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996710/
https://www.ncbi.nlm.nih.gov/pubmed/29904401
http://dx.doi.org/10.3892/etm.2018.6115
_version_ 1783330925855113216
author Xie, Deng'e
Lu, Chen
Zhu, Ying
Zhu, Sulan
Yang, Er-Jiang
Jin, Xin
author_facet Xie, Deng'e
Lu, Chen
Zhu, Ying
Zhu, Sulan
Yang, Er-Jiang
Jin, Xin
author_sort Xie, Deng'e
collection PubMed
description We conducted this study to analyze the sperm DNA fragmentation index, conventional semen parameters, blood microelements and seminal plasma reactive oxygen species (ROS) in patients with male infertility to determine the association between each of the above male physiological parameters and DNA fragmentation index and infertility. Eighty cases of infertile males and 20 cases of normal males with children were divided into the infertility and control groups, respectively. Sperm DNA fragmentation index, conventional semen parameters, serum microelement content and seminal plasma ROS levels were detected, and the existing correlation between sperm DNA fragmentation index and the various physiological parameters were studied. The sperm DNA fragmentation index had no correlation with conventional sperm parameters. Our results demonstrated that zinc, lead and magnesium ions in the serum microelements were correlated with sperm DNA fragmentation (p<0.05). Upon an increase in zinc and lead serum concentration, there was a subsequent increase in sperm DNA fragmentation (p=0.008). Furthermore, when magnesium ion increased, it also caused an increase in sperm DNA fragmentation (p<0.05). The seminal plasma ROS of infertile males was higher than that of males with children (p<0.05). Our results suggest that sperm DNA fragmentation index is closely associated with the infertility rate and microelements of serum and seminal plasma ROS can impact the formation of sperm DNA fragmentation. Therefore, the sperm DNA fragmentation index can serve as an important parameter to assess male infertility.
format Online
Article
Text
id pubmed-5996710
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-59967102018-06-14 Analysis on the association between sperm DNA fragmentation index and conventional semen parameters, blood microelements and seminal plasma ROS in male patients with infertility Xie, Deng'e Lu, Chen Zhu, Ying Zhu, Sulan Yang, Er-Jiang Jin, Xin Exp Ther Med Articles We conducted this study to analyze the sperm DNA fragmentation index, conventional semen parameters, blood microelements and seminal plasma reactive oxygen species (ROS) in patients with male infertility to determine the association between each of the above male physiological parameters and DNA fragmentation index and infertility. Eighty cases of infertile males and 20 cases of normal males with children were divided into the infertility and control groups, respectively. Sperm DNA fragmentation index, conventional semen parameters, serum microelement content and seminal plasma ROS levels were detected, and the existing correlation between sperm DNA fragmentation index and the various physiological parameters were studied. The sperm DNA fragmentation index had no correlation with conventional sperm parameters. Our results demonstrated that zinc, lead and magnesium ions in the serum microelements were correlated with sperm DNA fragmentation (p<0.05). Upon an increase in zinc and lead serum concentration, there was a subsequent increase in sperm DNA fragmentation (p=0.008). Furthermore, when magnesium ion increased, it also caused an increase in sperm DNA fragmentation (p<0.05). The seminal plasma ROS of infertile males was higher than that of males with children (p<0.05). Our results suggest that sperm DNA fragmentation index is closely associated with the infertility rate and microelements of serum and seminal plasma ROS can impact the formation of sperm DNA fragmentation. Therefore, the sperm DNA fragmentation index can serve as an important parameter to assess male infertility. D.A. Spandidos 2018-06 2018-05-02 /pmc/articles/PMC5996710/ /pubmed/29904401 http://dx.doi.org/10.3892/etm.2018.6115 Text en Copyright: © Xie et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Xie, Deng'e
Lu, Chen
Zhu, Ying
Zhu, Sulan
Yang, Er-Jiang
Jin, Xin
Analysis on the association between sperm DNA fragmentation index and conventional semen parameters, blood microelements and seminal plasma ROS in male patients with infertility
title Analysis on the association between sperm DNA fragmentation index and conventional semen parameters, blood microelements and seminal plasma ROS in male patients with infertility
title_full Analysis on the association between sperm DNA fragmentation index and conventional semen parameters, blood microelements and seminal plasma ROS in male patients with infertility
title_fullStr Analysis on the association between sperm DNA fragmentation index and conventional semen parameters, blood microelements and seminal plasma ROS in male patients with infertility
title_full_unstemmed Analysis on the association between sperm DNA fragmentation index and conventional semen parameters, blood microelements and seminal plasma ROS in male patients with infertility
title_short Analysis on the association between sperm DNA fragmentation index and conventional semen parameters, blood microelements and seminal plasma ROS in male patients with infertility
title_sort analysis on the association between sperm dna fragmentation index and conventional semen parameters, blood microelements and seminal plasma ros in male patients with infertility
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996710/
https://www.ncbi.nlm.nih.gov/pubmed/29904401
http://dx.doi.org/10.3892/etm.2018.6115
work_keys_str_mv AT xiedenge analysisontheassociationbetweenspermdnafragmentationindexandconventionalsemenparametersbloodmicroelementsandseminalplasmarosinmalepatientswithinfertility
AT luchen analysisontheassociationbetweenspermdnafragmentationindexandconventionalsemenparametersbloodmicroelementsandseminalplasmarosinmalepatientswithinfertility
AT zhuying analysisontheassociationbetweenspermdnafragmentationindexandconventionalsemenparametersbloodmicroelementsandseminalplasmarosinmalepatientswithinfertility
AT zhusulan analysisontheassociationbetweenspermdnafragmentationindexandconventionalsemenparametersbloodmicroelementsandseminalplasmarosinmalepatientswithinfertility
AT yangerjiang analysisontheassociationbetweenspermdnafragmentationindexandconventionalsemenparametersbloodmicroelementsandseminalplasmarosinmalepatientswithinfertility
AT jinxin analysisontheassociationbetweenspermdnafragmentationindexandconventionalsemenparametersbloodmicroelementsandseminalplasmarosinmalepatientswithinfertility