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Rapamycin provides anti-epileptogenic effect in a rat model of post-traumatic epilepsy via deactivation of mTOR signaling pathway

The mammalian target of rapamycin (mTOR) signaling pathway has attracted much attention in recent years. However, the contribution of mTOR activation to the development of post-traumatic epilepsy (PTE) remains largely unknown. The purpose of the present study was to investigate the activation of mTO...

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Autores principales: Wang, Feng, Chen, Fuxiang, Wang, Genbo, Wei, Shushan, Fang, Fu, Kang, Dezhi, Lin, Yuanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996717/
https://www.ncbi.nlm.nih.gov/pubmed/29904395
http://dx.doi.org/10.3892/etm.2018.6004
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author Wang, Feng
Chen, Fuxiang
Wang, Genbo
Wei, Shushan
Fang, Fu
Kang, Dezhi
Lin, Yuanxiang
author_facet Wang, Feng
Chen, Fuxiang
Wang, Genbo
Wei, Shushan
Fang, Fu
Kang, Dezhi
Lin, Yuanxiang
author_sort Wang, Feng
collection PubMed
description The mammalian target of rapamycin (mTOR) signaling pathway has attracted much attention in recent years. However, the contribution of mTOR activation to the development of post-traumatic epilepsy (PTE) remains largely unknown. The purpose of the present study was to investigate the activation of mTOR signaling in a rat model of FeCl(2)-induced PTE, and to explore the potential effect of its specific inhibitor rapamycin. The results indicated that the expression levels of p-mTOR and p-P70S6K, the overactivation biomarkers of mTOR signaling, increased significantly in hippocampal and perilesional cortex following PTE induction. Notably, they were significantly decreased in the aformementioned brain regions following rapamycin treatment. Furthermore, the frequency and number of behavioral seizures and epileptic brain injury were also greatly reduced. These results suggest that hyperactivation of the mTOR signaling pathway is a crucial mechanism of PTE development, and it may be considered a novel therapeutic target for PTE treatment.
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spelling pubmed-59967172018-06-14 Rapamycin provides anti-epileptogenic effect in a rat model of post-traumatic epilepsy via deactivation of mTOR signaling pathway Wang, Feng Chen, Fuxiang Wang, Genbo Wei, Shushan Fang, Fu Kang, Dezhi Lin, Yuanxiang Exp Ther Med Articles The mammalian target of rapamycin (mTOR) signaling pathway has attracted much attention in recent years. However, the contribution of mTOR activation to the development of post-traumatic epilepsy (PTE) remains largely unknown. The purpose of the present study was to investigate the activation of mTOR signaling in a rat model of FeCl(2)-induced PTE, and to explore the potential effect of its specific inhibitor rapamycin. The results indicated that the expression levels of p-mTOR and p-P70S6K, the overactivation biomarkers of mTOR signaling, increased significantly in hippocampal and perilesional cortex following PTE induction. Notably, they were significantly decreased in the aformementioned brain regions following rapamycin treatment. Furthermore, the frequency and number of behavioral seizures and epileptic brain injury were also greatly reduced. These results suggest that hyperactivation of the mTOR signaling pathway is a crucial mechanism of PTE development, and it may be considered a novel therapeutic target for PTE treatment. D.A. Spandidos 2018-06 2018-03-28 /pmc/articles/PMC5996717/ /pubmed/29904395 http://dx.doi.org/10.3892/etm.2018.6004 Text en Copyright: © Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Wang, Feng
Chen, Fuxiang
Wang, Genbo
Wei, Shushan
Fang, Fu
Kang, Dezhi
Lin, Yuanxiang
Rapamycin provides anti-epileptogenic effect in a rat model of post-traumatic epilepsy via deactivation of mTOR signaling pathway
title Rapamycin provides anti-epileptogenic effect in a rat model of post-traumatic epilepsy via deactivation of mTOR signaling pathway
title_full Rapamycin provides anti-epileptogenic effect in a rat model of post-traumatic epilepsy via deactivation of mTOR signaling pathway
title_fullStr Rapamycin provides anti-epileptogenic effect in a rat model of post-traumatic epilepsy via deactivation of mTOR signaling pathway
title_full_unstemmed Rapamycin provides anti-epileptogenic effect in a rat model of post-traumatic epilepsy via deactivation of mTOR signaling pathway
title_short Rapamycin provides anti-epileptogenic effect in a rat model of post-traumatic epilepsy via deactivation of mTOR signaling pathway
title_sort rapamycin provides anti-epileptogenic effect in a rat model of post-traumatic epilepsy via deactivation of mtor signaling pathway
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996717/
https://www.ncbi.nlm.nih.gov/pubmed/29904395
http://dx.doi.org/10.3892/etm.2018.6004
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