Lipase catalyzed synthesis of antimicrobial andrographolide derivatives

In this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors. Amano lipase AK from Pseudomonas fluorescens was used for the synthesis of two new acylated andrographolide derivatives. Two new compoun...

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Detalles Bibliográficos
Autores principales: Patil, Harshal S., Jadhav, Dipesh D., Paul, Ajay, Mulani, Fayaj A., Karegaonkar, Shrikant J., Thulasiram, Hirekodathakallu V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Chemistry   
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996720/
https://www.ncbi.nlm.nih.gov/pubmed/29900286
http://dx.doi.org/10.1016/j.dib.2018.03.103
Descripción
Sumario:In this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors. Amano lipase AK from Pseudomonas fluorescens was used for the synthesis of two new acylated andrographolide derivatives. Two new compounds, andrographolide-14-propionate and andrographolide-14-caproate were characterized by various spectral studies. These two derivatives showed more antimicrobial activity than andrographolide.

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