Lipase catalyzed synthesis of antimicrobial andrographolide derivatives

In this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors. Amano lipase AK from Pseudomonas fluorescens was used for the synthesis of two new acylated andrographolide derivatives. Two new compoun...

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Autores principales: Patil, Harshal S., Jadhav, Dipesh D., Paul, Ajay, Mulani, Fayaj A., Karegaonkar, Shrikant J., Thulasiram, Hirekodathakallu V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Chemistry   
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996720/
https://www.ncbi.nlm.nih.gov/pubmed/29900286
http://dx.doi.org/10.1016/j.dib.2018.03.103
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author Patil, Harshal S.
Jadhav, Dipesh D.
Paul, Ajay
Mulani, Fayaj A.
Karegaonkar, Shrikant J.
Thulasiram, Hirekodathakallu V.
author_facet Patil, Harshal S.
Jadhav, Dipesh D.
Paul, Ajay
Mulani, Fayaj A.
Karegaonkar, Shrikant J.
Thulasiram, Hirekodathakallu V.
author_sort Patil, Harshal S.
collection PubMed
description In this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors. Amano lipase AK from Pseudomonas fluorescens was used for the synthesis of two new acylated andrographolide derivatives. Two new compounds, andrographolide-14-propionate and andrographolide-14-caproate were characterized by various spectral studies. These two derivatives showed more antimicrobial activity than andrographolide.
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spelling pubmed-59967202018-06-13 Lipase catalyzed synthesis of antimicrobial andrographolide derivatives Patil, Harshal S. Jadhav, Dipesh D. Paul, Ajay Mulani, Fayaj A. Karegaonkar, Shrikant J. Thulasiram, Hirekodathakallu V. Data Brief Chemistry    In this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors. Amano lipase AK from Pseudomonas fluorescens was used for the synthesis of two new acylated andrographolide derivatives. Two new compounds, andrographolide-14-propionate and andrographolide-14-caproate were characterized by various spectral studies. These two derivatives showed more antimicrobial activity than andrographolide. Elsevier 2018-03-28 /pmc/articles/PMC5996720/ /pubmed/29900286 http://dx.doi.org/10.1016/j.dib.2018.03.103 Text en © 2018 Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Chemistry   
Patil, Harshal S.
Jadhav, Dipesh D.
Paul, Ajay
Mulani, Fayaj A.
Karegaonkar, Shrikant J.
Thulasiram, Hirekodathakallu V.
Lipase catalyzed synthesis of antimicrobial andrographolide derivatives
title Lipase catalyzed synthesis of antimicrobial andrographolide derivatives
title_full Lipase catalyzed synthesis of antimicrobial andrographolide derivatives
title_fullStr Lipase catalyzed synthesis of antimicrobial andrographolide derivatives
title_full_unstemmed Lipase catalyzed synthesis of antimicrobial andrographolide derivatives
title_short Lipase catalyzed synthesis of antimicrobial andrographolide derivatives
title_sort lipase catalyzed synthesis of antimicrobial andrographolide derivatives
topic Chemistry   
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996720/
https://www.ncbi.nlm.nih.gov/pubmed/29900286
http://dx.doi.org/10.1016/j.dib.2018.03.103
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