Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow

We demonstrate in vivo volumetric optical microangiography at [Formula: see text] by the use of 1.6 MHz Fourier domain mode-locking swept source optical coherence tomography and an effective 36 kHz microelectromechanical system (MEMS) scanner. We propose an intervolume analysis strategy to contrast...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Wei, Xu, Jingjiang, Baran, Utku, Song, Shaozhen, Qin, Wan, Qi, Xiaoli, Wang, Ruikang K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Photo-Optical Instrumentation Engineers 2016
Materias:
Research Papers: Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996864/
https://www.ncbi.nlm.nih.gov/pubmed/26968387
http://dx.doi.org/10.1117/1.JBO.21.3.036005
_version_ 1783330958004453376
author Wei, Wei
Xu, Jingjiang
Baran, Utku
Song, Shaozhen
Qin, Wan
Qi, Xiaoli
Wang, Ruikang K.
author_facet Wei, Wei
Xu, Jingjiang
Baran, Utku
Song, Shaozhen
Qin, Wan
Qi, Xiaoli
Wang, Ruikang K.
author_sort Wei, Wei
collection PubMed
description We demonstrate in vivo volumetric optical microangiography at [Formula: see text] by the use of 1.6 MHz Fourier domain mode-locking swept source optical coherence tomography and an effective 36 kHz microelectromechanical system (MEMS) scanner. We propose an intervolume analysis strategy to contrast the dynamic blood flow signal from the static tissue background. The proposed system is demonstrated by imaging cerebral blood flow in mice in vivo. For the first time, imaging speed, sensitivity, and temporal resolution become possible for a direct four-dimensional observation of microcirculations within live body parts.
format Online
Article
Text
id pubmed-5996864
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Society of Photo-Optical Instrumentation Engineers
record_format MEDLINE/PubMed
spelling pubmed-59968642018-06-13 Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow Wei, Wei Xu, Jingjiang Baran, Utku Song, Shaozhen Qin, Wan Qi, Xiaoli Wang, Ruikang K. J Biomed Opt Research Papers: Imaging We demonstrate in vivo volumetric optical microangiography at [Formula: see text] by the use of 1.6 MHz Fourier domain mode-locking swept source optical coherence tomography and an effective 36 kHz microelectromechanical system (MEMS) scanner. We propose an intervolume analysis strategy to contrast the dynamic blood flow signal from the static tissue background. The proposed system is demonstrated by imaging cerebral blood flow in mice in vivo. For the first time, imaging speed, sensitivity, and temporal resolution become possible for a direct four-dimensional observation of microcirculations within live body parts. Society of Photo-Optical Instrumentation Engineers 2016-03-11 2016-03 /pmc/articles/PMC5996864/ /pubmed/26968387 http://dx.doi.org/10.1117/1.JBO.21.3.036005 Text en © The Authors. https://creativecommons.org/licenses/by/3.0/ Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
spellingShingle Research Papers: Imaging
Wei, Wei
Xu, Jingjiang
Baran, Utku
Song, Shaozhen
Qin, Wan
Qi, Xiaoli
Wang, Ruikang K.
Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow
title Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow
title_full Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow
title_fullStr Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow
title_full_unstemmed Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow
title_short Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow
title_sort intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow
topic Research Papers: Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996864/
https://www.ncbi.nlm.nih.gov/pubmed/26968387
http://dx.doi.org/10.1117/1.JBO.21.3.036005
work_keys_str_mv AT weiwei intervolumeanalysistoachievefourdimensionalopticalmicroangiographyforobservationofdynamicbloodflow
AT xujingjiang intervolumeanalysistoachievefourdimensionalopticalmicroangiographyforobservationofdynamicbloodflow
AT baranutku intervolumeanalysistoachievefourdimensionalopticalmicroangiographyforobservationofdynamicbloodflow
AT songshaozhen intervolumeanalysistoachievefourdimensionalopticalmicroangiographyforobservationofdynamicbloodflow
AT qinwan intervolumeanalysistoachievefourdimensionalopticalmicroangiographyforobservationofdynamicbloodflow
AT qixiaoli intervolumeanalysistoachievefourdimensionalopticalmicroangiographyforobservationofdynamicbloodflow
AT wangruikangk intervolumeanalysistoachievefourdimensionalopticalmicroangiographyforobservationofdynamicbloodflow

Ejemplares similares