Cargando…

Modeling Chronic Toxicity: A Comparison of Experimental Variability With (Q)SAR/Read-Across Predictions

This study compares the accuracy of (Q)SAR/read-across predictions with the experimental variability of chronic lowest-observed-adverse-effect levels (LOAELs) from in vivo experiments. We could demonstrate that predictions of the lazy structure-activity relationships (lazar) algorithm within the app...

Descripción completa

Detalles Bibliográficos
Autores principales:	Helma, Christoph, Vorgrimmler, David, Gebele, Denis, Gütlein, Martin, Engeli, Barbara, Zarn, Jürg, Schilter, Benoit, Lo Piparo, Elena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996880/ https://www.ncbi.nlm.nih.gov/pubmed/29922154 http://dx.doi.org/10.3389/fphar.2018.00413

Ejemplares similares

lazar: a modular predictive toxicology framework
por: Maunz, Andreas, et al.
Publicado: (2013)

Nano-Lazar: Read across Predictions for Nanoparticle Toxicities with Calculated and Measured Properties
por: Helma, Christoph, et al.
Publicado: (2017)

In Silico Toxicology Data Resources to Support Read-Across and (Q)SAR
por: Pawar, Gopal, et al.
Publicado: (2019)

Innovative Strategies to Develop Chemical Categories Using a Combination of Structural and Toxicological Properties
por: Batke, Monika, et al.
Publicado: (2016)

Toxic Responses Induced at High Doses May Affect Benchmark Doses
por: Zarn, Jürg A., et al.
Publicado: (2020)

RAID: Regression Analysis–Based Inductive DNA Microarray for Precise Read-Across
por: Amano, Yuto, et al.
Publicado: (2022)

A Comparison of Nine Machine Learning Mutagenicity Models and Their Application for Predicting Pyrrolizidine Alkaloids
por: Helma, Christoph, et al.
Publicado: (2021)

CheS-Mapper 2.0 for visual validation of (Q)SAR models
por: Gütlein, Martin, et al.
Publicado: (2014)

Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis
por: Han, Lifeng, et al.
Publicado: (2019)

Variable Secondary Metabolite Profiles Across Cultivars of Curcuma longa L. and C. aromatica Salisb.
por: Kulyal, Poonam, et al.
Publicado: (2021)

Current pesticide dietary risk assessment in light of comparable animal study NOAELs after chronic and short-termed exposure durations
por: Zarn, Jürg A., et al.
Publicado: (2017)

Editorial: Toxic Plant Proteins as Experimental Drugs for Human Pathologies
por: Polito, Letizia, et al.
Publicado: (2021)

UPLC/Q-TOFMS-Based Metabolomics Approach to Reveal the Protective Role of Other Herbs in An-Gong-Niu-Huang Wan Against the Hepatorenal Toxicity of Cinnabar and Realgar
por: Xia, Fangbo, et al.
Publicado: (2018)

Metabolism and toxicity of usnic acid and barbatic acid based on microsomes, S9 fraction, and 3T3 fibroblasts in vitro combined with a UPLC-Q-TOF-MS method
por: Wang, Hanxue, et al.
Publicado: (2023)

Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 alpha-demethylase and aromatase.
por: Zarn, Jürg A, et al.
Publicado: (2003)

Osthole Attenuates Macrophage Activation in Experimental Asthma by Inhibitingthe NF-ĸB/MIF Signaling Pathway
por: Li, Ruyi, et al.
Publicado: (2021)

Toxic Constituents Index: A Toxicity-Calibrated Quantitative Evaluation Approach for the Precise Toxicity Prediction of the Hypertoxic Phytomedicine—Aconite
por: Zhang, Ding-kun, et al.
Publicado: (2016)

Reading a Story: Different Degrees of Learning in Different Learning Environments
por: Giannini, Anna Maria, et al.
Publicado: (2017)

Nephroprotective potential of Polyalthia longifolia roots against vancomycin-induced renal toxicity in experimental animals
por: Das, Kuntal, et al.
Publicado: (2023)

Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals
por: Ain, Qurat Ul, et al.
Publicado: (2023)

Optimal experimental design for efficient toxicity testing in microphysiological systems: A bone marrow application
por: Cairns, Jonathan, et al.
Publicado: (2023)

Toxicity of Tetradium ruticarpum: Subacute Toxicity Assessment and Metabolomic Identification of Relevant Biomarkers
por: Shan, Qiyuan, et al.
Publicado: (2022)

Exploring potential mechanism of ciwujia tablets for insomnia by UPLC-Q-TOF-MS/MS, network pharmacology, and experimental validation
por: Liu, Hongda, et al.
Publicado: (2022)

Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies
por: Saravanan, Harish, et al.
Publicado: (2023)

Metabolic Activation of the Toxic Natural Products From Herbal and Dietary Supplements Leading to Toxicities
por: Wang, Yi-Kun, et al.
Publicado: (2021)

Acute Toxicity-Supported Chronic Toxicity Prediction: A k-Nearest Neighbor Coupled Read-Across Strategy
por: Chavan, Swapnil, et al.
Publicado: (2015)

Predictive Toxicity: Grand Challenges
por: Pelkonen, Olavi
Publicado: (2010)

Hydroxychloroquine-induced Retinal Toxicity
por: Yusuf, Imran H., et al.
Publicado: (2023)

Metabolomics Reveals the Mechanisms for the Pulmonary Toxicity of Siegesbeckia orientalis L. and the Toxicity-Reducing Effect of Processing
por: Jiang, Ting, et al.
Publicado: (2021)

Editorial: Toxicity Mechanisms, Exposure, Toxicokinetic and Risk Assessment Aspects of Metals, Toxic for Animals and Humans
por: Zhu, Yanzhu, et al.
Publicado: (2022)

Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across
por: Russo, Daniel P., et al.
Publicado: (2019)

Ethnopharmacological Field Study of Three Q'eqchi Communities in Guatemala
por: Vargas, Jorge Mario, et al.
Publicado: (2018)

How the Toxin got its Toxicity
por: Jackson, Timothy N. W., et al.
Publicado: (2020)

Editorial: Toxicity mechanisms, exposure, toxicokinetic and risk assessment aspects of metals, toxic for animals and humans, Volume II
por: Zhu, Yanzhu, et al.
Publicado: (2023)

Comparative Analysis for the Performance of Long-Read-Based Structural Variation Detection Pipelines in Tandem Repeat Regions
por: Guo, Mingkun, et al.
Publicado: (2021)

Affecting children’s knowledge about rational use of medicines using read-along videos of pictorial storybooks
por: Bakaruddin, Syafi’ah, et al.
Publicado: (2022)

Multi-Component Herbal Products in the Prevention and Treatment of Chemotherapy-Associated Toxicity and Side Effects: A Review on Experimental and Clinical Evidences
por: Fu, Bowen, et al.
Publicado: (2018)

In vitro Toxicity Testing in the Twenty-First Century
por: Roggen, Erwin L.
Publicado: (2011)

Toxic Effects of Trichloroethylene on Rat Neuroprogenitor Cells
por: Salama, Mohamed M., et al.
Publicado: (2018)

Toxicity and Pharmacogenomic Biomarkers in Breast Cancer Chemotherapy
por: Al-Mahayri, Zeina N., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_e7cdchcn9q0dump34lhoc720p6