Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia

Excessive activation of neutrophils results in the release of neutrophil elastase (NE), which leads to lung injury in severe pneumonia. Previously, we demonstrated a novel immune subversion mechanism involving microbial exploitation of this NE ability, which eventually promotes disruption of the pul...

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Detalles Bibliográficos
Autores principales: Domon, Hisanori, Nagai, Kosuke, Maekawa, Tomoki, Oda, Masataka, Yonezawa, Daisuke, Takeda, Wataru, Hiyoshi, Takumi, Tamura, Hikaru, Yamaguchi, Masaya, Kawabata, Shigetada, Terao, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996908/
https://www.ncbi.nlm.nih.gov/pubmed/29922273
http://dx.doi.org/10.3389/fimmu.2018.00732

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