Cargando…

Arf6 and its ZEB1-EPB41L5 mesenchymal axis are required for both mesenchymal- and amoeboid-type invasion of cancer cells

Modes of cancer invasion interchange between the mesenchymal type and amoeboid type in response to the microenvironment, in which RhoA and Rac1 are selectively required to perform different modes of actin-cytoskeletal remodeling. Membrane remodeling is another integral part of invasion. Arf6 regulat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Handa, Haruka, Hashimoto, Ari, Hashimoto, Shigeru, Sabe, Hisataka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Commentaries
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997150/ https://www.ncbi.nlm.nih.gov/pubmed/27754741 http://dx.doi.org/10.1080/21541248.2016.1249043

Ejemplares similares

ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance
por: Hashimoto, A, et al.
Publicado: (2016)

EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial–mesenchymal transition
por: Hirano, Mariko, et al.
Publicado: (2008)

High expression of EPB41L5, an integral component of the Arf6-driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the tongue
por: Otsuka, Yutaro, et al.
Publicado: (2016)

Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer
por: Hashimoto, Shigeru, et al.
Publicado: (2016)

P53- and mevalonate pathway–driven malignancies require Arf6 for metastasis and drug resistance
por: Hashimoto, Ari, et al.
Publicado: (2016)

Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model
por: Otsuka, Yutaro, et al.
Publicado: (2018)

Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer
por: Hashimoto, Ari, et al.
Publicado: (2021)

Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells
por: Handa, Haruka, et al.
Publicado: (2018)

High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer
por: Tsutaho, Akio, et al.
Publicado: (2020)

Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma
por: Hashimoto, Ari, et al.
Publicado: (2022)

The EGFR-GEP100-Arf6-AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis(†)
por: Sabe, Hisataka, et al.
Publicado: (2009)

Engagement of Overexpressed Her2 with GEP100 Induces Autonomous Invasive Activities and Provides a Biomarker for Metastases of Lung Adenocarcinoma
por: Menju, Toshi, et al.
Publicado: (2011)

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer
por: Hashimoto, Shigeru, et al.
Publicado: (2019)

GEP100-Arf6-AMAP1-Cortactin Pathway Frequently Used in Cancer Invasion Is Activated by VEGFR2 to Promote Angiogenesis
por: Hashimoto, Ari, et al.
Publicado: (2011)

Melanoma cells adopt features of both mesenchymal and amoeboid migration within confining channels
por: Gabbireddy, Sairisheel R., et al.
Publicado: (2021)

Tumor Invasion Optimization by Mesenchymal-Amoeboid Heterogeneity
por: Hecht, Inbal, et al.
Publicado: (2015)

Circ-EPB41L5 regulates the host gene EPB41L5 via sponging miR-19a to repress glioblastoma tumorigenesis
por: Lv, Tao, et al.
Publicado: (2020)

Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity
por: Oikawa, Tsukasa, et al.
Publicado: (2018)

WIP Regulates Persistence of Cell Migration and Ruffle Formation in Both Mesenchymal and Amoeboid Modes of Motility
por: Banon-Rodriguez, Inmaculada, et al.
Publicado: (2013)

Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway
por: Das, Shreyas, et al.
Publicado: (2009)

Cross-disease communication between cancer and heart failure provides a rational approach to prevention and treatment of both diseases
por: Takada, Shingo, et al.
Publicado: (2022)

Lnc-EPB41-Protein Interactions Associated with Congenital Pouch Colon
por: Gupta, Sonal, et al.
Publicado: (2018)

KRAS, MYC, and ARF6: inseparable relationships cooperatively promote cancer malignancy and immune evasion
por: Sabe, Hisataka
Publicado: (2023)

Erratum: Tumor Invasion Optimization by Mesenchymal-Amoeboid Heterogeneity
por: Hecht, Inbal, et al.
Publicado: (2015)

Chemotactic signaling in mesenchymal cells compared to amoeboid cells
por: Vorotnikov, Alexander V., et al.
Publicado: (2014)

ADP-Ribosylation Factor 6 Pathway Acts as a Key Executor of Mesenchymal Tumor Plasticity
por: Hashimoto, Ari, et al.
Publicado: (2023)

The activation of INF2 by Piezo1/Ca(2+) is required for mesenchymal to amoeboid transition in confined environments
por: Kar, Neelakshi, et al.
Publicado: (2023)

Clinical prognostic implications of EPB41L4A expression in multiple myeloma
por: Zhang, Weilong, et al.
Publicado: (2020)

Characterizing the function of EPB41L4A in the predisposition to papillary thyroid carcinoma
por: Comiskey, Daniel F., et al.
Publicado: (2020)

The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells
por: Paňková, K., et al.
Publicado: (2009)

Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells
por: Taddei, Maria Letizia, et al.
Publicado: (2014)

Septins Enable T Cell Contact Guidance via Amoeboid-Mesenchymal Switch
por: Zhovmer, Alexander S., et al.
Publicado: (2023)

Rab5c promotes AMAP1–PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion
por: Onodera, Yasuhito, et al.
Publicado: (2012)

Identification of a Two-Gene (PML-EPB41) Signature With Independent Prognostic Value in Osteosarcoma
por: Liu, Shengye, et al.
Publicado: (2020)

Tissue-specific requirements for specific domains in the FERM protein Moe/Epb4.1l5 during early zebrafish development
por: Christensen, Arne K, et al.
Publicado: (2008)

Pag3/Papα/Kiaa0400, a Gtpase-Activating Protein for Adp-Ribosylation Factor (Arf), Regulates Arf6 in Fcγ Receptor–Mediated Phagocytosis of Macrophages
por: Uchida, Hiroshi, et al.
Publicado: (2001)

HDAC10 Inhibits Cervical Cancer Progression through Downregulating the HDAC10-microRNA-223-EPB41L3 Axis
por: Gu, Yuan Yuan, et al.
Publicado: (2022)

PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness
por: Vaškovičová, Katarína, et al.
Publicado: (2015)

Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments
por: Talkenberger, Katrin, et al.
Publicado: (2017)

Drug Resistance in Glioma Cells Induced by a Mesenchymal–Amoeboid Migratory Switch
por: Ketchen, Sophie E., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pr14gksdhvmoajelj4rb8aakpk