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Tolerogenic β2-glycoprotein I DNA vaccine and FK506 as an adjuvant attenuates experimental obstetric antiphospholipid syndrome

DNA vaccines have recently emerged as a therapeutic agent for treating autoimmune diseases, such as multiple sclerosis. Antiphospholipid antibody syndrome (APS) is an autoimmune disease characterized by β2-glycoprotein I (β2-GPI)-targeting antiphospholipid antibodies (APAs) and vascular thrombosis o...

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Detalles Bibliográficos
Autores principales: Chao, Ya-Hsuan, Chen, Der-Yuan, Lan, Joung-Liang, Tang, Kuo-Tung, Lin, Chi-Chien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997307/
https://www.ncbi.nlm.nih.gov/pubmed/29894515
http://dx.doi.org/10.1371/journal.pone.0198821