OG716: Designing a fit-for-purpose lantibiotic for the treatment of Clostridium difficile infections

Lantibiotics continue to offer an untapped pipeline for the development of novel antibiotics. We report here the discovery of a novel lantibiotic for the treatment of C. difficile infection (CDI). The leads were selected from a library of over 300 multiple substitution variants of the lantibiotic Mu...

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Detalles Bibliográficos
Autores principales: Kers, Johan A., DeFusco, Anthony W., Park, Jae H., Xu, Jin, Pulse, Mark E., Weiss, William J., Handfield, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997364/
https://www.ncbi.nlm.nih.gov/pubmed/29894469
http://dx.doi.org/10.1371/journal.pone.0197467

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