Cargando…
Ischemic Modified Albumin Predicts Critical Coronary Artery Disease in Unstable Angina Pectoris and Non-ST-Elevation Myocardial Infarction
BACKGROUND: In this study, whether ischemia modified albumin (IMA) has a role in showing severity or criticality of coronary arteries in patients with unstable angina pectoris (USAP)/non-ST-elevation myocardial infarction (NSTEMI) was assessed. METHODS: A total of 65 patients (40 male (M) and 25 fem...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997412/ https://www.ncbi.nlm.nih.gov/pubmed/29904441 http://dx.doi.org/10.14740/jocmr3417w |
_version_ | 1783331040739196928 |
---|---|
author | Demirtas, Abdullah Orhan Karabag, Turgut Demirtas, Derya |
author_facet | Demirtas, Abdullah Orhan Karabag, Turgut Demirtas, Derya |
author_sort | Demirtas, Abdullah Orhan |
collection | PubMed |
description | BACKGROUND: In this study, whether ischemia modified albumin (IMA) has a role in showing severity or criticality of coronary arteries in patients with unstable angina pectoris (USAP)/non-ST-elevation myocardial infarction (NSTEMI) was assessed. METHODS: A total of 65 patients (40 male (M) and 25 female (F) patients; mean age 59.7 ± 12.1 years) with the initial diagnosis of USAP/NSTEMI were included in this study. The levels of IMA, troponin T, creatine kinase MB (CK-MB), C-reactive protein (CRP), brain natriuretic peptide (BNP), creatinine, lipid panel, and whole blood count were measured from venous blood obtained from each patient within 3 h after the onset of symptoms. A 50% or greater coronary lumen stenosis of any coronary vessel or lateral branch was considered as critical stenosis. The severity of coronary artery disease (CAD) was assessed using the Gensini scoring system. RESULTS: IMA was significantly higher in patients with critical coronary artery stenosis (median, 206 vs. 23; P < 0.001). There was a weak correlation between the Gensini score and IMA; whereas there was a moderate correlation between the Gensini score and BNP levels (r = 0.44, P = 0.02). CONCLUSION: The level of IMA can predict the criticality of CAD; however, it cannot predict the severity of CAD according to Gensini score in patients with USAP/NSTEMI. |
format | Online Article Text |
id | pubmed-5997412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59974122018-06-14 Ischemic Modified Albumin Predicts Critical Coronary Artery Disease in Unstable Angina Pectoris and Non-ST-Elevation Myocardial Infarction Demirtas, Abdullah Orhan Karabag, Turgut Demirtas, Derya J Clin Med Res Original Article BACKGROUND: In this study, whether ischemia modified albumin (IMA) has a role in showing severity or criticality of coronary arteries in patients with unstable angina pectoris (USAP)/non-ST-elevation myocardial infarction (NSTEMI) was assessed. METHODS: A total of 65 patients (40 male (M) and 25 female (F) patients; mean age 59.7 ± 12.1 years) with the initial diagnosis of USAP/NSTEMI were included in this study. The levels of IMA, troponin T, creatine kinase MB (CK-MB), C-reactive protein (CRP), brain natriuretic peptide (BNP), creatinine, lipid panel, and whole blood count were measured from venous blood obtained from each patient within 3 h after the onset of symptoms. A 50% or greater coronary lumen stenosis of any coronary vessel or lateral branch was considered as critical stenosis. The severity of coronary artery disease (CAD) was assessed using the Gensini scoring system. RESULTS: IMA was significantly higher in patients with critical coronary artery stenosis (median, 206 vs. 23; P < 0.001). There was a weak correlation between the Gensini score and IMA; whereas there was a moderate correlation between the Gensini score and BNP levels (r = 0.44, P = 0.02). CONCLUSION: The level of IMA can predict the criticality of CAD; however, it cannot predict the severity of CAD according to Gensini score in patients with USAP/NSTEMI. Elmer Press 2018-07 2018-06-04 /pmc/articles/PMC5997412/ /pubmed/29904441 http://dx.doi.org/10.14740/jocmr3417w Text en Copyright 2018, Demirtas et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Demirtas, Abdullah Orhan Karabag, Turgut Demirtas, Derya Ischemic Modified Albumin Predicts Critical Coronary Artery Disease in Unstable Angina Pectoris and Non-ST-Elevation Myocardial Infarction |
title | Ischemic Modified Albumin Predicts Critical Coronary Artery Disease in Unstable Angina Pectoris and Non-ST-Elevation Myocardial Infarction |
title_full | Ischemic Modified Albumin Predicts Critical Coronary Artery Disease in Unstable Angina Pectoris and Non-ST-Elevation Myocardial Infarction |
title_fullStr | Ischemic Modified Albumin Predicts Critical Coronary Artery Disease in Unstable Angina Pectoris and Non-ST-Elevation Myocardial Infarction |
title_full_unstemmed | Ischemic Modified Albumin Predicts Critical Coronary Artery Disease in Unstable Angina Pectoris and Non-ST-Elevation Myocardial Infarction |
title_short | Ischemic Modified Albumin Predicts Critical Coronary Artery Disease in Unstable Angina Pectoris and Non-ST-Elevation Myocardial Infarction |
title_sort | ischemic modified albumin predicts critical coronary artery disease in unstable angina pectoris and non-st-elevation myocardial infarction |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997412/ https://www.ncbi.nlm.nih.gov/pubmed/29904441 http://dx.doi.org/10.14740/jocmr3417w |
work_keys_str_mv | AT demirtasabdullahorhan ischemicmodifiedalbuminpredictscriticalcoronaryarterydiseaseinunstableanginapectorisandnonstelevationmyocardialinfarction AT karabagturgut ischemicmodifiedalbuminpredictscriticalcoronaryarterydiseaseinunstableanginapectorisandnonstelevationmyocardialinfarction AT demirtasderya ischemicmodifiedalbuminpredictscriticalcoronaryarterydiseaseinunstableanginapectorisandnonstelevationmyocardialinfarction |