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Chiral cell sliding drives left-right asymmetric organ twisting
Polarized epithelial morphogenesis is an essential process in animal development. While this process is mostly attributed to directional cell intercalation, it can also be induced by other mechanisms. Using live-imaging analysis and a three-dimensional vertex model, we identified ‘cell sliding,’ a n...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997448/ https://www.ncbi.nlm.nih.gov/pubmed/29891026 http://dx.doi.org/10.7554/eLife.32506 |
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author | Inaki, Mikiko Hatori, Ryo Nakazawa, Naotaka Okumura, Takashi Ishibashi, Tomoki Kikuta, Junichi Ishii, Masaru Matsuno, Kenji Honda, Hisao |
author_facet | Inaki, Mikiko Hatori, Ryo Nakazawa, Naotaka Okumura, Takashi Ishibashi, Tomoki Kikuta, Junichi Ishii, Masaru Matsuno, Kenji Honda, Hisao |
author_sort | Inaki, Mikiko |
collection | PubMed |
description | Polarized epithelial morphogenesis is an essential process in animal development. While this process is mostly attributed to directional cell intercalation, it can also be induced by other mechanisms. Using live-imaging analysis and a three-dimensional vertex model, we identified ‘cell sliding,’ a novel mechanism driving epithelial morphogenesis, in which cells directionally change their position relative to their subjacent (posterior) neighbors by sliding in one direction. In Drosophila embryonic hindgut, an initial left-right (LR) asymmetry of the cell shape (cell chirality in three dimensions), which occurs intrinsically before tissue deformation, is converted through LR asymmetric cell sliding into a directional axial twisting of the epithelial tube. In a Drosophila inversion mutant showing inverted cell chirality and hindgut rotation, cell sliding occurs in the opposite direction to that in wild-type. Unlike directional cell intercalation, cell sliding does not require junctional remodeling. Cell sliding may also be involved in other cases of LR-polarized epithelial morphogenesis. |
format | Online Article Text |
id | pubmed-5997448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59974482018-06-13 Chiral cell sliding drives left-right asymmetric organ twisting Inaki, Mikiko Hatori, Ryo Nakazawa, Naotaka Okumura, Takashi Ishibashi, Tomoki Kikuta, Junichi Ishii, Masaru Matsuno, Kenji Honda, Hisao eLife Developmental Biology Polarized epithelial morphogenesis is an essential process in animal development. While this process is mostly attributed to directional cell intercalation, it can also be induced by other mechanisms. Using live-imaging analysis and a three-dimensional vertex model, we identified ‘cell sliding,’ a novel mechanism driving epithelial morphogenesis, in which cells directionally change their position relative to their subjacent (posterior) neighbors by sliding in one direction. In Drosophila embryonic hindgut, an initial left-right (LR) asymmetry of the cell shape (cell chirality in three dimensions), which occurs intrinsically before tissue deformation, is converted through LR asymmetric cell sliding into a directional axial twisting of the epithelial tube. In a Drosophila inversion mutant showing inverted cell chirality and hindgut rotation, cell sliding occurs in the opposite direction to that in wild-type. Unlike directional cell intercalation, cell sliding does not require junctional remodeling. Cell sliding may also be involved in other cases of LR-polarized epithelial morphogenesis. eLife Sciences Publications, Ltd 2018-06-12 /pmc/articles/PMC5997448/ /pubmed/29891026 http://dx.doi.org/10.7554/eLife.32506 Text en © 2018, Inaki et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology Inaki, Mikiko Hatori, Ryo Nakazawa, Naotaka Okumura, Takashi Ishibashi, Tomoki Kikuta, Junichi Ishii, Masaru Matsuno, Kenji Honda, Hisao Chiral cell sliding drives left-right asymmetric organ twisting |
title | Chiral cell sliding drives left-right asymmetric organ twisting |
title_full | Chiral cell sliding drives left-right asymmetric organ twisting |
title_fullStr | Chiral cell sliding drives left-right asymmetric organ twisting |
title_full_unstemmed | Chiral cell sliding drives left-right asymmetric organ twisting |
title_short | Chiral cell sliding drives left-right asymmetric organ twisting |
title_sort | chiral cell sliding drives left-right asymmetric organ twisting |
topic | Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997448/ https://www.ncbi.nlm.nih.gov/pubmed/29891026 http://dx.doi.org/10.7554/eLife.32506 |
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