Cargando…

Novel Surgical Treatments for Gastroesophageal Reflux Disease: Systematic Review of Magnetic Sphincter Augmentation and Electric Stimulation Therapy

Electric stimulation therapy (EST) and magnetic sphincter augmentation (MSA) represent novel methods for the surgical treatment of gastroesophageal reflux disease (GERD). The aim of this review was to assess the effectiveness and safety of EST and magnetic sphincter augmentation device (MSAD) comapr...

Descripción completa

Detalles Bibliográficos
Autores principales: Stanak, Michal, Erdos, Judit, Hawlik, Katharina, Birsan, Tudor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997468/
https://www.ncbi.nlm.nih.gov/pubmed/29915626
http://dx.doi.org/10.14740/gr1024w
_version_ 1783331054664286208
author Stanak, Michal
Erdos, Judit
Hawlik, Katharina
Birsan, Tudor
author_facet Stanak, Michal
Erdos, Judit
Hawlik, Katharina
Birsan, Tudor
author_sort Stanak, Michal
collection PubMed
description Electric stimulation therapy (EST) and magnetic sphincter augmentation (MSA) represent novel methods for the surgical treatment of gastroesophageal reflux disease (GERD). The aim of this review was to assess the effectiveness and safety of EST and magnetic sphincter augmentation device (MSAD) comapred to laparoscopic fundoplication (LF) and proton pump inhibitor therapy (in case of EST). We performed a systematic literature search without restrictions on publication dates in five electronic databases (MEDLINE, EMBASE, the Cochrane library, PubMed, and Centre for Reviews and Dissemination), complemented by hand search, search in trial registries, and documentation provided by the manufacturers. No study passed inclusion criteria for analyzing EST effectiveness. Concerning safety, lead erosion through the esophagus and trocar perforation of the small bowel occurred in 2.4% of patients (in one study). Only the registry study fulfilled inclusion criteria for effectiveness analysis of MSAD. The crucial outcome of GERD-health-related quality of life (HRQL) score improved from 20 to 3 points in MSAD patients, and from 23 to 3.5 points in LF patients. However, the LF patients were in a more severe stage of the disease. The results yield indefinite conclusions about the use of both MSAD and EST. Clinical effectiveness and safety of both MSAD and EST are not sufficiently proven and are yet to be supported by high quality evidence from randomized controlled trials.
format Online
Article
Text
id pubmed-5997468
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elmer Press
record_format MEDLINE/PubMed
spelling pubmed-59974682018-06-18 Novel Surgical Treatments for Gastroesophageal Reflux Disease: Systematic Review of Magnetic Sphincter Augmentation and Electric Stimulation Therapy Stanak, Michal Erdos, Judit Hawlik, Katharina Birsan, Tudor Gastroenterology Res Review Electric stimulation therapy (EST) and magnetic sphincter augmentation (MSA) represent novel methods for the surgical treatment of gastroesophageal reflux disease (GERD). The aim of this review was to assess the effectiveness and safety of EST and magnetic sphincter augmentation device (MSAD) comapred to laparoscopic fundoplication (LF) and proton pump inhibitor therapy (in case of EST). We performed a systematic literature search without restrictions on publication dates in five electronic databases (MEDLINE, EMBASE, the Cochrane library, PubMed, and Centre for Reviews and Dissemination), complemented by hand search, search in trial registries, and documentation provided by the manufacturers. No study passed inclusion criteria for analyzing EST effectiveness. Concerning safety, lead erosion through the esophagus and trocar perforation of the small bowel occurred in 2.4% of patients (in one study). Only the registry study fulfilled inclusion criteria for effectiveness analysis of MSAD. The crucial outcome of GERD-health-related quality of life (HRQL) score improved from 20 to 3 points in MSAD patients, and from 23 to 3.5 points in LF patients. However, the LF patients were in a more severe stage of the disease. The results yield indefinite conclusions about the use of both MSAD and EST. Clinical effectiveness and safety of both MSAD and EST are not sufficiently proven and are yet to be supported by high quality evidence from randomized controlled trials. Elmer Press 2018-06 2018-05-31 /pmc/articles/PMC5997468/ /pubmed/29915626 http://dx.doi.org/10.14740/gr1024w Text en Copyright 2018, Stanak et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Stanak, Michal
Erdos, Judit
Hawlik, Katharina
Birsan, Tudor
Novel Surgical Treatments for Gastroesophageal Reflux Disease: Systematic Review of Magnetic Sphincter Augmentation and Electric Stimulation Therapy
title Novel Surgical Treatments for Gastroesophageal Reflux Disease: Systematic Review of Magnetic Sphincter Augmentation and Electric Stimulation Therapy
title_full Novel Surgical Treatments for Gastroesophageal Reflux Disease: Systematic Review of Magnetic Sphincter Augmentation and Electric Stimulation Therapy
title_fullStr Novel Surgical Treatments for Gastroesophageal Reflux Disease: Systematic Review of Magnetic Sphincter Augmentation and Electric Stimulation Therapy
title_full_unstemmed Novel Surgical Treatments for Gastroesophageal Reflux Disease: Systematic Review of Magnetic Sphincter Augmentation and Electric Stimulation Therapy
title_short Novel Surgical Treatments for Gastroesophageal Reflux Disease: Systematic Review of Magnetic Sphincter Augmentation and Electric Stimulation Therapy
title_sort novel surgical treatments for gastroesophageal reflux disease: systematic review of magnetic sphincter augmentation and electric stimulation therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997468/
https://www.ncbi.nlm.nih.gov/pubmed/29915626
http://dx.doi.org/10.14740/gr1024w
work_keys_str_mv AT stanakmichal novelsurgicaltreatmentsforgastroesophagealrefluxdiseasesystematicreviewofmagneticsphincteraugmentationandelectricstimulationtherapy
AT erdosjudit novelsurgicaltreatmentsforgastroesophagealrefluxdiseasesystematicreviewofmagneticsphincteraugmentationandelectricstimulationtherapy
AT hawlikkatharina novelsurgicaltreatmentsforgastroesophagealrefluxdiseasesystematicreviewofmagneticsphincteraugmentationandelectricstimulationtherapy
AT birsantudor novelsurgicaltreatmentsforgastroesophagealrefluxdiseasesystematicreviewofmagneticsphincteraugmentationandelectricstimulationtherapy