Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic

EC1456 is a folate-tubulysin conjugate constructed with an all-D enantiomeric spacer/linker configuration. When tested against folate receptor (FR)-positive cells, EC1456 demonstrated dose-responsive activity with an approximate 1000-fold level of specificity. Treatment of nude mice bearing FR-posit...

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Detalles Bibliográficos
Autores principales: Reddy, Joseph A., Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Dircksen, Christina, Vetzel, Marilynn, Kleindl, Paul, Santhapuram, Hari, Vlahov, Iontcho R., Leamon, Christopher P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997627/
https://www.ncbi.nlm.nih.gov/pubmed/29895863
http://dx.doi.org/10.1038/s41598-018-27320-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997627/
https://www.ncbi.nlm.nih.gov/pubmed/29895863
http://dx.doi.org/10.1038/s41598-018-27320-5

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