Heterologous expression of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum rescues Chinese Hamster Ovary cells deficient in the Kennedy phosphatidylcholine biosynthesis pathway

The plasmodial CTP:phosphocholine cytidylyltransferase (PfCCT) is a promising antimalarial target, which can be inhibited to exploit the need for increased lipid biosynthesis during the erythrocytic life stage of Plasmodium falciparum. Notable structural and regulatory differences of plasmodial and...

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Detalles Bibliográficos
Autores principales: Marton, Lívia, Hajdú, Fanni, Nagy, Gergely N., Kucsma, Nóra, Szakács, Gergely, Vértessy, Beáta G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997628/
https://www.ncbi.nlm.nih.gov/pubmed/29895950
http://dx.doi.org/10.1038/s41598-018-27183-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997628/
https://www.ncbi.nlm.nih.gov/pubmed/29895950
http://dx.doi.org/10.1038/s41598-018-27183-w

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