Suppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity

A line of studies strongly suggest that the intravenous anesthetic, propofol, suppresses mitochondrial oxygen metabolism. It is also indicated that propofol induces the cell death in a reactive oxygen species (ROS)-dependent manner. Because hypoxia-inducible factor 1 (HIF-1) is a transcription facto...

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Detalles Bibliográficos
Autores principales: Sumi, Chisato, Okamoto, Akihisa, Tanaka, Hiromasa, Kusunoki, Munenori, Shoji, Tomohiro, Uba, Takeo, Adachi, Takehiko, Iwai, Teppei, Nishi, Kenichiro, Harada, Hiroshi, Bono, Hidemasa, Matsuo, Yoshiyuki, Hirota, Kiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997661/
https://www.ncbi.nlm.nih.gov/pubmed/29895831
http://dx.doi.org/10.1038/s41598-018-27220-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997661/
https://www.ncbi.nlm.nih.gov/pubmed/29895831
http://dx.doi.org/10.1038/s41598-018-27220-8

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