Cargando…
Suppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity
A line of studies strongly suggest that the intravenous anesthetic, propofol, suppresses mitochondrial oxygen metabolism. It is also indicated that propofol induces the cell death in a reactive oxygen species (ROS)-dependent manner. Because hypoxia-inducible factor 1 (HIF-1) is a transcription facto...
Autores principales: | Sumi, Chisato, Okamoto, Akihisa, Tanaka, Hiromasa, Kusunoki, Munenori, Shoji, Tomohiro, Uba, Takeo, Adachi, Takehiko, Iwai, Teppei, Nishi, Kenichiro, Harada, Hiroshi, Bono, Hidemasa, Matsuo, Yoshiyuki, Hirota, Kiichi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997661/ https://www.ncbi.nlm.nih.gov/pubmed/29895831 http://dx.doi.org/10.1038/s41598-018-27220-8 |
Ejemplares similares
-
HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death
por: Okamoto, Akihisa, et al.
Publicado: (2017) -
Propofol induces a metabolic switch to glycolysis and cell death in a mitochondrial electron transport chain-dependent manner
por: Sumi, Chisato, et al.
Publicado: (2018) -
Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma
por: Sumi, Chisato, et al.
Publicado: (2019) -
Propofol inhibits stromatoxin-1-sensitive voltage-dependent K(+) channels in pancreatic β-cells and enhances insulin secretion
por: Kusunoki, Munenori, et al.
Publicado: (2019) -
Sevoflurane Does Not Promote the Colony-Forming Ability of Human Mesenchymal Glioblastoma Stem Cells In Vitro
por: Shoji, Tomohiro, et al.
Publicado: (2022)