A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies

CAR T-cell therapies hold great promise for treating a range of malignancies but are however challenged by the complexity of their production and by the adverse events related to their activity. Here we report the development of the CubiCAR, a tri-functional CAR architecture that enables CAR T-cell...

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Autores principales: Valton, Julien, Guyot, Valerie, Boldajipour, Bijan, Sommer, Cesar, Pertel, Thomas, Juillerat, Alexandre, Duclert, Aymeric, Sasu, Barbra Johnson, Duchateau, Philippe, Poirot, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997667/
https://www.ncbi.nlm.nih.gov/pubmed/29895885
http://dx.doi.org/10.1038/s41598-018-27264-w
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author Valton, Julien
Guyot, Valerie
Boldajipour, Bijan
Sommer, Cesar
Pertel, Thomas
Juillerat, Alexandre
Duclert, Aymeric
Sasu, Barbra Johnson
Duchateau, Philippe
Poirot, Laurent
author_facet Valton, Julien
Guyot, Valerie
Boldajipour, Bijan
Sommer, Cesar
Pertel, Thomas
Juillerat, Alexandre
Duclert, Aymeric
Sasu, Barbra Johnson
Duchateau, Philippe
Poirot, Laurent
author_sort Valton, Julien
collection PubMed
description CAR T-cell therapies hold great promise for treating a range of malignancies but are however challenged by the complexity of their production and by the adverse events related to their activity. Here we report the development of the CubiCAR, a tri-functional CAR architecture that enables CAR T-cell detection, purification and on-demand depletion by the FDA-approved antibody Rituximab. This novel architecture has the potential to streamline the manufacturing of CAR T-cells, allow their tracking and improve their overall safety.
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spelling pubmed-59976672018-06-21 A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies Valton, Julien Guyot, Valerie Boldajipour, Bijan Sommer, Cesar Pertel, Thomas Juillerat, Alexandre Duclert, Aymeric Sasu, Barbra Johnson Duchateau, Philippe Poirot, Laurent Sci Rep Article CAR T-cell therapies hold great promise for treating a range of malignancies but are however challenged by the complexity of their production and by the adverse events related to their activity. Here we report the development of the CubiCAR, a tri-functional CAR architecture that enables CAR T-cell detection, purification and on-demand depletion by the FDA-approved antibody Rituximab. This novel architecture has the potential to streamline the manufacturing of CAR T-cells, allow their tracking and improve their overall safety. Nature Publishing Group UK 2018-06-12 /pmc/articles/PMC5997667/ /pubmed/29895885 http://dx.doi.org/10.1038/s41598-018-27264-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Valton, Julien
Guyot, Valerie
Boldajipour, Bijan
Sommer, Cesar
Pertel, Thomas
Juillerat, Alexandre
Duclert, Aymeric
Sasu, Barbra Johnson
Duchateau, Philippe
Poirot, Laurent
A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies
title A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies
title_full A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies
title_fullStr A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies
title_full_unstemmed A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies
title_short A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies
title_sort versatile safeguard for chimeric antigen receptor t-cell immunotherapies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997667/
https://www.ncbi.nlm.nih.gov/pubmed/29895885
http://dx.doi.org/10.1038/s41598-018-27264-w
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