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NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor
NCAM1 and NCAM2 have ectodomains consisting of 5 Ig domains followed by 2 membrane-proximal FnIII domains. In this study we investigate and compare the structures and functions of these FnIII domains. The NCAM1 and -2 FnIII2 domains both contain a Walker A motif. In NCAM1 binding of ATP to this moti...
Autores principales: | Rasmussen, Kim Krighaar, Falkesgaard, Maria Hansen, Winther, Malene, Roed, Nikolaj Kulahin, Quistgaard, Christine Louise, Teisen, Marie Nygaard, Edslev, Sofie Marie, Petersen, David Leander, Aljubouri, Ali, Christensen, Claus, Thulstrup, Peter Waaben, Lo Leggio, Leila, Teilum, Kaare, Walmod, Peter Schledermann |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997747/ https://www.ncbi.nlm.nih.gov/pubmed/29895898 http://dx.doi.org/10.1038/s41598-018-27089-7 |
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